机构：[1]Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China shandagxf@126.com
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摘要：
To investigate the effects on lymphangiogenesis and angiogenesis of orthotopic implantation of lung cancer in nude mice with antisense oligonucleotides of VEGF-C.
The model in nude mice was established with orthotopic implantation for the human lung cancer cell line A549. Thirty nude mice were randomized into three groups: PBS control group, sense oligonucleotides control group and antisense oligonucleotides group (AODN group). After treatments were completed, the expression of VEGF-C and lymphatic microvessel density (LMVD) and microvessel density (MVD) of lung cancer were detected by RT-PCR,Western Blot and immunohistochemistry.
The expression of VEGF-C in AODN group was inhibit significantly (P < 0.05). The LMVD in AODN group was decreased significantly (P < 0.1). Though the MVD in AODN group was also decreased, but there were no significant differences compared with control groups (P > 0.05).
The antisense oligonucleotides of VEGF-C can inhibit the expression of VEGF-C in nude mice of orthotopic implantation of lung cancer. It could inhibit the lymphangiogenesis.
语种：
中文
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第一作者：
第一作者机构：[1]Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China shandagxf@126.com
推荐引用方式(GB/T 7714)：
Guo Xu-Feng,等.[Effects on lymphangiogenesis and angiogenesis of lung cancer with antisense oligonucleotides of vascular endothelial growth factor C].[J].Zhonghua wai ke za zhi [Chinese journal of surgery].2008,46(9):694-6.
