机构：[a]The George Institute for Global Health, University of Sydney, Australia[b]School of Public Health, The University of Hong Kong, Hong Kong, China[c]Department of Medicine and Pharmacology, University of Western Australia, Nedlands, Australia[d]Cardiovascular and Metabolic Diseases Etiology Research Center, Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, South Korea[e]School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China[f]Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[g]Department of Public Health, Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Japan[h]Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, South Korea[i]Cancer Epidemiology Centre, The Cancer Council, Victoria, Australia[j]The George Institute for Global Health, Nuffield Department of Population Health, University of Oxford, UK[k]Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA
To assess whether body mass index (BMI) modifies the associations of lipids with coronary heart disease (CHD).
In the Asia Pacific Cohort Studies Collaboration, total cholesterol (TC), high density lipoprotein cholesterol (HDLC) and triglycerides (TG) were measured for 333,297, 71,777 and 84,015 participants, respectively. All participants had measured BMI, categorized into underweight, normal, high-normal, overweight and obese, using standard definitions. For each BMI subgroup the effects of lipids on CHD were estimated per 1 standard deviation (SD) increase using Cox proportional hazard models, stratified by study and sex, adjusted for age and smoking. They were compared across the BMI groups, testing for interactions.
In the analyses for TC, HDLC and TG, there were 3121, 714 and 808 CHD events during a mean follow-up of 6.7 years. The risk of CHD increased monotonically with increasing TC and decreasing HDLC in all BMI subgroups without evidence of heterogeneity (p for interaction > 0.4). In contrast, the hazard ratio for CHD for a one SD increase in log-transformed TG increased from 1.07 (95%CI 0.72-1.59) in underweight, 1.26 (1.10-1.44) in normal weight, 1.27 (1.08-1.49) in high-normal weight, 1.37 (1.22-1.55) in overweight, to 1.61(1.30-1.99) in obesity (p = 0.01 for interaction trend). These associations were attenuated (p = 0.07 for interaction) but remained significant in the overweight and obese after further adjustment for TC and HDLC.
Greater excess body weight exacerbated the effects of TG, but not TC or HDLC, on CHD, suggesting that additional effort is required to reduce TG in the overweight and obese.
基金：
National Health and Medical Research Council (NHMRC) of Australia's program grant 571281.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
无
最新[2025]版：
大类|3 区医学
小类|3 区公共卫生、环境卫生与职业卫生
第一作者：
第一作者机构：[a]The George Institute for Global Health, University of Sydney, Australia
通讯作者：
通讯机构：[*]The George Institute for Global Health, PO Box M201, Missenden Road, Camperdown, NSW 2050, Sydney, Australia
推荐引用方式(GB/T 7714)：
Yoichiro Hirakawa,Tai-Hing Lam,Timothy Welborn,et al.The impact of body mass index on the associations of lipids with the risk of coronary heart disease in the Asia Pacific region.[J].Preventive medicine reports.2016,3:79-82.doi:10.1016/j.pmedr.2015.12.012.
APA：
Yoichiro Hirakawa,Tai-Hing Lam,Timothy Welborn,Hyeon Chang Kim,Suzanne Ho...&MarkWoodward.(2016).The impact of body mass index on the associations of lipids with the risk of coronary heart disease in the Asia Pacific region..Preventive medicine reports,3,
MLA：
Yoichiro Hirakawa,et al."The impact of body mass index on the associations of lipids with the risk of coronary heart disease in the Asia Pacific region.".Preventive medicine reports 3.(2016):79-82
