In twenty patients with ectopic pregnancy who received treatment using methotrexate-citrovorum factor in an individualized reduced dose regimen 17 cases were successfully treated, 4 required one course of therapy, 8 required two courses, 4 required three courses, only 1 required four courses, according to the difference in the speed of hCG reduction. The success rate was 85.0%, two cases got intrauterine pregnancy within 6 months after the treatment. Three ruptured cases during treatment were operated upon. The pathologic findings at the ectopic site were chorionic bleeding, necroses, with dissolution of trophoblastic cells.