机构：[1]Emergency Department, Xuanwu Hospital, Capital Medical University, Beijing, China.急诊科首都医科大学宣武医院[2]Department of Critical Care and Emergency Medicine, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.[3]Department of Animal Laboratory, School of Basic Medical Sciences, Capital Medical University, Beijing, China.[4]Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.[5]Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China.[6]School of Basic Medicine, Shenyang Medical College, Shenyang, Liaoning, China.[7]Division of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China.[8]Department of Radiology, Liaoning Provincial People’s Hospital, Shenyang, Liaoning, China.[9]The First Research Institute, Ministry of the Public Security, Beijing, China.[10]Department of Epidemiology and Health Statistics, Shenyang Medical College, Shenyang, Liaoning, China.[11]Hainan Medical University, Haikou, Hainan, China.[12]Division of Statistics, School of Economics, Shanghai University, Shanghai, China.[13]Research Center of Financial Information, Shanghai University, Shanghai, China.[14]Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA.[15]Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Gallstone disease (GSD) is a common biliary tract disease worldwide. Previous studies have investigated the association of apolipoprotein E (APOE) E4 with GSD and reported inconsistent results.
In this paper, we conducted meta-analyses to examine whether APOE E4 is associated with the risk of GSD. A systematic literature search was performed in PubMed, Cochrane Library, EMBASE, and Google Scholar using the following inclusion criteria: 1) Studies on human subjects; 2) subjects in the control group must undergo ultrasound GSD screening, and presence of GSD in the experiment group can be clearly determined, e.g., diagnosis of GSD through ultrasound screening or a previous history of cholecystectomy or cholelithiasis; 3) the studies reported APOE genotype data (APOE E4+ vs. E4-) for subjects with and without GSD. In all the meta-analyses, we used random-effects models to calculate the odds ratios (ORs) as a measure of association as well as the corresponding confidence intervals (CIs).
Our literature search found 13 publications with 14 studies, including a total of 1632 GSD patients and 5001 controls, that met the eligibility criteria and were included in the meta-analyses. We did not find a significant association between APOE E4 and risk of GSD (OR = 1.23, 95% CI: 0.89-1.68; p = 0.205). No significant associations were observed in subgroup analyses by gender and mean age. We obtained similar insignificant findings if an additive model was used, if subjects who had E2E4 genotype were excluded, or if low-quality studies were excluded.
Our meta-analysis found insufficient evidence for the effect of APOE E4 on GSD risk. Future studies with large sample sizes that control for important confounding/risk factors are needed to validate our findings and to explore other genetic loci that might affect GSD risk.
基金：
National Natural Science Foundation of China [81660329, 81771493]; Key Science and Technology Program of Shaanxi Province, China [2015SF011]; College Student Innovation & Entrepreneurship Project of Liaoning Province [201410164000016]; College Student Innovation & Entrepreneurship Training Program of Hainan Medical University [HYCX2015054]; NIH/NIA [R01AG036042]; Illinois Department of Public Health
第一作者机构：[1]Emergency Department, Xuanwu Hospital, Capital Medical University, Beijing, China.[2]Department of Critical Care and Emergency Medicine, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Li Lizhuo,Qiao Xin,Wang Xia,et al.The association between apolipoprotein E and gallstone disease: an updated meta-analysis.[J].BMC medical genetics.2019,20(1):109.doi:10.1186/s12881-019-0843-6.
APA：
Li Lizhuo,Qiao Xin,Wang Xia,Liu Di,Xue Qingmu...&Yang Jingyun.(2019).The association between apolipoprotein E and gallstone disease: an updated meta-analysis..BMC medical genetics,20,(1)
MLA：
Li Lizhuo,et al."The association between apolipoprotein E and gallstone disease: an updated meta-analysis.".BMC medical genetics 20..1(2019):109
