机构：[1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院细胞生物学研究室[2]Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China[3]Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100069, China[4]Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing 100069, China
Endogenous neural stem cells (NSCs) exist in the central canal of mammalian spinal cords. Under normal conditions, these NSCs remain quiescent and express FoxJ1. After spinal cord injury (SCI), the endogenous NSCs of a heterogeneous nature are activated and proliferate and migrate towards the lesion site and mainly differentiate into astrocytes to repair the injured tissue. In vitro, spinal cord NSCs are multipotent and can differentiate into neurons, astrocytes, and oligodendrocytes. The altered microenvironments after SCI play key roles on the fate determination of activated NSCs, especially on the neuronal specification potential. Studies show that the activated spinal cord NSCs can generate interneurons when transplanted into the adult hippocampus. In addition, the spinal cord NSCs exhibit low immunogenicity in a transplantation context, thus implicating a promising therapeutic potential on SCI recovery. Here, we summarize the characteristics of spinal cord NSCs, especially their properties after injury. With a better understanding of endogenous NSCs under normal and SCI conditions, we may be able to employ endogenous NSCs for SCI repair in the future.
基金：
Stem Cell and Translation National Key Project [2016YFA0101403]; National Natural Science Foundation of China [81661130160, 81422014, 81561138004]; Beijing Municipal Natural Science Foundation [5142005]; Beijing Talents Foundation [2017000021223TD03]; Support Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan [CITTCD20180333]; Beijing Medical System High Level Talent Award [2015-3-063]; Beijing Municipal Health Commission Fund [PXM 2018_026283_000002]; Beijing One Hundred, Thousand, and Ten Thousand Talents Fund [2018A03]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201706]; Royal Society-Newton Advanced Fellowship [NA150482]
第一作者机构：[1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China[2]Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Sumei,Chen Zhiguo.Employing Endogenous NSCs to Promote Recovery of Spinal Cord Injury.[J].Stem cells international.2019,2019:1958631.doi:10.1155/2019/1958631.
APA：
Liu Sumei&Chen Zhiguo.(2019).Employing Endogenous NSCs to Promote Recovery of Spinal Cord Injury..Stem cells international,2019,
MLA：
Liu Sumei,et al."Employing Endogenous NSCs to Promote Recovery of Spinal Cord Injury.".Stem cells international 2019.(2019):1958631
