机构：[a]Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China神经内科中美神经科学研究所首都医科大学宣武医院[b]Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA[c]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[d]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经外科首都医科大学宣武医院[e]Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China麻醉手术科首都医科大学宣武医院[f]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA
To investigate the effect of general anesthesia (GA) on functional outcomes and complications rates in acute ischemic stroke (AIS) patients treated with mechanical thrombectomy (MT) compared to the use of local anesthesia (LA) at the puncture site.
This observational study was based on a prospectively registry study. AIS patients underwent MT with GA or LA from January 2013 to October 2017 were included. The primary outcome was the modified Rankin Scale (mRS) score at 90?days post-intervention. Furthermore, we assessed the long-term outcome of these patients. Multivariable logistic regression analysis was conducted to adjust for confounders.
We enrolled 187 AIS patients in this study, patients in GA group had a similar mRS score compared to LA group at 90?days (2 [IQR, 1-4] vs 2.5 [IQR, 1-4], P?=?.917). No differences were found in the rates of functional independence (mRS 0-2), no or minimal disability (mRS 0-1), and mortality (mRS 6) between the 2 groups at 90?days post-intervention as well as long-term follow-up. The procedure-related complications and serious adverse events were similar between the LA group and GA group (P?>?.05 each). In multivariable analysis, GA use was not associated with functional outcomes.
AIS patients who received GA during MT had similar functional outcomes and complications rates compared to patients received LA.
Copyright ? 2019 Elsevier B.V. All rights reserved.
基金：
This study was supported by National Key R&D Program of China
(2017YFC1308401; 2016YFC1301502); Chang Jiang Scholars Program
(#T2014251) from the Chinese Ministry of Education; National Natural
Science Foundation of China (81701287; 81871022; 81601006);
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201706); The “mission”
talent project of Beijing Municipal Administration of Hospitals
(SML20150802); Beijing Municipal Administration of Hospitals' Youth
Programme (QML20170802); Ten Thousand Talent Program.
第一作者机构：[a]Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[*1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, No. 45, Changchun Street, Xicheng District, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Longfei Wu,Ashutosh P. Jadhav,Wenbo Zhao,et al.General anesthesia vs local anesthesia during mechanical thrombectomy in acute ischemic stroke.[J].Journal of the neurological sciences.2019,403:13-18.doi:10.1016/j.jns.2019.05.034.
APA：
Longfei Wu,Ashutosh P. Jadhav,Wenbo Zhao,Di Wu,Jian Chen...&Xunming Ji.(2019).General anesthesia vs local anesthesia during mechanical thrombectomy in acute ischemic stroke..Journal of the neurological sciences,403,
MLA：
Longfei Wu,et al."General anesthesia vs local anesthesia during mechanical thrombectomy in acute ischemic stroke.".Journal of the neurological sciences 403.(2019):13-18
