机构：[1]Department of Neurobiology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China[2]Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA[3]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经外科[4]Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China[5]Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA[6]Neuromodulation Research, Medtronic Inc., Minneapolis, MN, USA[7]Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden[8]Department of Neurological Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
High-frequency spinal cord stimulation (SCS) administered below the sensory threshold (subparesthetic) can inhibit pain, but the mechanisms remain obscure. We examined how different SCS paradigms applied at intensities below the threshold of Aβ-fiber activation (sub-sensory threshold) affect spinal nociceptive transmission in rats after an L5 spinal nerve ligation (SNL).
Electrophysiology was used to record local field potential (LFP) at L4 spinal cord before, during, and 0-60?min after SCS in SNL rats. LFP was evoked by high-intensity paired-pulse test stimulation (5 mA, 0.2 msec, 400?msec interval) at the sciatic nerve. Epidural SCS was delivered through a miniature electrode placed at T13-L1 and L2-L3 spinal levels. Four patterns of SCS (200 Hz, 1 msec; 500 Hz, 0.5 msec; 1200 Hz; 0.2 msec; 10,000 Hz, 0.024?msec, 30?min, bipolar) were tested at 90% Aβ-threshold as a subthreshold intensity. As a positive control, traditional SCS (50 Hz, 0.2 msec) was tested at 100% Aβ-plateau as a suprathreshold intensity.
Traditional suprathreshold SCS at T13-L1 level significantly reduced LFP to C-fiber inputs (C-LFP). Subthreshold SCS of 200 and 500 Hz, but not 1200 or 10,000 Hz, also reduced C-LFP, albeit to a lesser extent than did traditional SCS (n = 7-10/group). When SCS was applied at the L2-L3 level, only traditional SCS and subthreshold SCS of 200 Hz inhibited C-LFP (n = 8-10/group).
Traditional suprathreshold SCS acutely inhibits spinal nociceptive transmission. Low-frequency subthreshold SCS with a long pulse width (200 Hz, 1 msec), but not higher-frequency SCS, also attenuates C-LFP.
? 2019 International Neuromodulation Society.
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外文
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出版当年[2018]版：
大类|3 区医学
小类|3 区临床神经病学3 区医学：研究与实验
最新[2023]版：
大类|3 区医学
小类|3 区临床神经病学3 区医学：研究与实验
第一作者：
第一作者机构：[1]Department of Neurobiology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China[2]Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
通讯作者：
通讯机构：[1]Department of Neurobiology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China[2]Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA[8]Department of Neurological Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
推荐引用方式(GB/T 7714)：
Fei Yang,Wanru Duan,Qian Huang,et al.Modulation of Spinal Nociceptive Transmission by Sub-Sensory Threshold Spinal Cord Stimulation in Rats After Nerve Injury.[J].NEUROMODULATION.2019,doi:10.1111/ner.12975.
APA：
Fei Yang,Wanru Duan,Qian Huang,Zhiyong Chen,Neil Ford...&Yun Guan.(2019).Modulation of Spinal Nociceptive Transmission by Sub-Sensory Threshold Spinal Cord Stimulation in Rats After Nerve Injury..NEUROMODULATION,,
MLA：
Fei Yang,et al."Modulation of Spinal Nociceptive Transmission by Sub-Sensory Threshold Spinal Cord Stimulation in Rats After Nerve Injury.".NEUROMODULATION .(2019)
