机构:[1]Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China内分泌科北京市老年病医疗研究中心[2]Department of Rheumatology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China 风湿免疫科北京市老年病医疗研究中心
The aim of this study was to investigate the risk factors for cognitive impairment in older people with diabetes.
This cross-sectional study included 2626 community-dwelling participants with diabetes aged ⩾55 years, living in Beijing, China. The participants were screened for risk factors, including smoking, obesity, hypertension, stroke, coronary heart disease, dyslipidemia, depression, apolipoprotein E (APOE) genotype, and low physical activity. Cognitive function was assessed with the scholarship-adjusted Mini-Mental State Examination (MMSE): MMSE ⩽17 for iliterate participants; MMSE ⩽20 for primary school graduates (⩾6 years of education); and MMSE ⩽24 for junior school graduates or above (⩾9 years of education).
The prevalence of cognitive impairment in older people with diabetes was 9.90%. Multiple logistic regression analysis demonstrated that stroke [odds ratio (OR) = 1.71, 95% confidence interval (CI) = 1.20-2.43], less than 0.5 h exercise per day (OR = 1.89, 95% CI = 1.37-2.61), and depression (OR = 1.64, 95% CI = 1.06-2.54), but not smoking, obesity, hypertension, dyslipidemia, and coronary heart disease, were independent risks for cognitive impairment in older people with diabetes. In addition, being married (OR = 0.66, 95% CI = 0.47-0.93) and urban living (OR = 0.33, 95% CI = 0.22-0.48) could decrease the risk of cognitive impairment.
Stroke, depression, and less than 0.5 h exercise per day were independent risks for cognitive impairment in older people with diabetes, whereas being married and urban living were protective.
第一作者机构:[1]Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China
通讯作者:
通讯机构:[*1]Department of Neurobiology, Geriatrics, and Neurology, Xuanwu Hospital, No. 45 Changchun St., Xicheng District, Beijing, China
推荐引用方式(GB/T 7714):
Xiu Shuangling,Liao Qiuju,Sun Lina,et al.Risk factors for cognitive impairment in older people with diabetes: a community-based study.[J].Therapeutic advances in endocrinology and metabolism.2019,10:2042018819836640.doi:10.1177/2042018819836640.
APA:
Xiu Shuangling,Liao Qiuju,Sun Lina&Chan Piu.(2019).Risk factors for cognitive impairment in older people with diabetes: a community-based study..Therapeutic advances in endocrinology and metabolism,10,
MLA:
Xiu Shuangling,et al."Risk factors for cognitive impairment in older people with diabetes: a community-based study.".Therapeutic advances in endocrinology and metabolism 10.(2019):2042018819836640