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Metal–Organic-Framework-Derived Carbon Nanostructures for Site-Specific Dual-Modality Photothermal/Photodynamic Thrombus Therapy

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收录情况： ◇ SCIE ◇ EI

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机构： [1]Department of Radiology, Xuanwu Hospital, Beijing 100053, P. R. China [2]Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, P. R. China [3]Department of Neurosurgery, Xuanwu Hospital, Beijing 100053, P. R. China

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关键词： carbon nanostructures photodynamic therapy photothermal therapy thrombus

摘要：

Although near-infrared (NIR)-light-mediated photothermal thrombolysis has been investigated to overcome the bleeding risk of clinical clot-busting agents, the secondary embolism of post-phototherapy fragments (>10 µm) for small vessels should not be ignored in this process. In this study, dual-modality photothermal/photodynamic thrombolysis is explored using targeting nanoagents with an emphasis on improving biosafety as well as ameliorating the thrombolytic effect. The nanoagents can actively target glycoprotein IIb/IIIa receptors on thrombus to initiate site-specific thrombolysis by hyperthermia and reactive oxygen species under NIR laser irradiation. In comparison to single photothermal thrombolysis, an 87.9% higher re-establishment rate of dual-modality photothermal/photodynamic thrombolysis by one-time treatment is achieved in a lower limb thrombosis model. The dual-modality thrombolysis can also avoid re-embolization after breaking fibrin into tiny fragments. All the results show that this strategy is a safe and validated protocol for thrombolysis, which fits the clinical translational trend of nanomedicine. © 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

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出版当年[2018]版：

大类 | 1 区

工程技术

小类 | 2 区化学综合 2 区材料科学：综合 2 区纳米科技

最新[2025]版：

大类 | 1 区

综合性期刊

小类 | 1 区化学：综合 1 区材料科学：综合 1 区纳米科技

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出版当年[2017]版：

Q1 NANOSCIENCE & NANOTECHNOLOGY Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

最新[2023]版：

Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY

影响因子： 14.3 最新[2023版] 16.3 最新五年平均 12.441 出版当年[2017版] 12.515 出版当年五年平均 9.034 出版前一年[2016版] 15.804 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Radiology, Xuanwu Hospital, Beijing 100053, P. R. China [2]Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, P. R. China

通讯作者：

通讯机构： [1]Department of Radiology, Xuanwu Hospital, Beijing 100053, P. R. China [2]Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, P. R. China

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Metal–Organic-Framework-Derived Carbon Nanostructures for Site-Specific Dual-Modality Photothermal/Photodynamic Thrombus Therapy

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