机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, No.45 Street Changchun, District Xichen, Beijing 100053, China内科系统神经内科神经科系统神经内科江苏省人民医院[2]School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, China[3]Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany[4]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China医技科室放射科医技科室放射科江苏省人民医院[5]Beijing Institute of Geriatrics, Beijing, China[6]National Clinical Research Center for Geriatric Disorders, Beijing, China[7]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China
Alzheimer's disease (AD) is the most common neurodegenerative disease in elderly individuals. We conducted this study to examine whether alterations in the fractional amplitudes of low-frequency fluctuations (fALFF) in the AD spectrum were frequency-dependent and symptom-relevant. A total of 43 patients with subjective cognitive decline (SCD), 52 with amnestic mild cognitive impairment (aMCI), 44 with Alzheimer's dementia (d-AD) and 55 well-matched controls participated in resting-state functional magnetic resonance imaging (rs-fMRI) scans. The amplitudes were measured using fALFF within the slow-4 (0.027-0.073 Hz) and slow-5 (0.01-0.027 Hz) bands. Repeated-measures analysis of variance was performed on fALFF within two bands and correlated with neuropsychological test scores. The significant main effects of frequency and group on fALFF differed widely across brain regions. There were more varied areas in the slow-5 band than the slow-4 band. The fALFF associated with primary disease effects was mainly distributed in the parietal lobe. Obvious frequency band and group interaction effects were observed in the left angular gyrus, left calcarine fissure and surrounding cortex, left superior cerebellum, left cuneus and right lingual gyrus. Neuropsychological tests scores were significantly correlated with the fALFF magnitude of the left cuneus and right lingual in the slow-5 band. Our results suggested that the AD continuum had abnormal amplitudes in intrinsic brain activity, and these abnormalities were frequency-dependent and mainly associated with the slow-5 band rather than the slow-4 band. This may guide the frequency choice of future rs-fMRI studies and provide new insights into the neuropathophysiology of AD.
第一作者机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, No.45 Street Changchun, District Xichen, Beijing 100053, China
通讯作者：
通讯机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, No.45 Street Changchun, District Xichen, Beijing 100053, China[2]School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, China[5]Beijing Institute of Geriatrics, Beijing, China[6]National Clinical Research Center for Geriatric Disorders, Beijing, China[7]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China
推荐引用方式(GB/T 7714)：
Liu Yang,Yan Yan,Yuxia Li,et al.Frequency-dependent changes in fractional amplitude of low-frequency oscillations in Alzheimer's disease: a resting-state fMRI study.[J].BRAIN IMAGING AND BEHAVIOR.2020,14(6):2187-2201.doi:10.1007/s11682-019-00169-6.
APA：
Liu Yang,Yan Yan,Yuxia Li,Xiaochen Hu,Jie Lu...&Ying Han.(2020).Frequency-dependent changes in fractional amplitude of low-frequency oscillations in Alzheimer's disease: a resting-state fMRI study..BRAIN IMAGING AND BEHAVIOR,14,(6)
MLA：
Liu Yang,et al."Frequency-dependent changes in fractional amplitude of low-frequency oscillations in Alzheimer's disease: a resting-state fMRI study.".BRAIN IMAGING AND BEHAVIOR 14..6(2020):2187-2201
