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Chinese Lupus Treatment and Research group (CSTAR) registry: X. family history in relation to lupus clinical and immunological manifestations

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机构： [a]Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China [b]Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China [c]Department of Rheumatology, Anhui Provincial Hospital, Anhui, China [d]Department of Rheumatology, Guangdong Provincial People's Hospital, Guangzhou, China [e]Department of Rheumatology, The First Affiliated Hospital of Zhengzhou University, Henan, China [f]Department of Rheumatology, The People's Hospital of Xinjiang Autonomous Region, Xinjiang, China [g]Department of Rheumatology, China-Japan Hospital, Beijing, China [h]Department of Rheumatology, Sino-Japanese Friendship Hospital of Jilin University, Jilin, China [i]Department of Rheumatology, Xiangya Hospital, Central South University, Hunan, China [j]Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu, China [k]Department of Rheumatology, Beijing Hospital, Beijing, China [l]Peking Union Medical College Hospital, China [m]The Affiliated Drum Tower Hospital of Nanjing University Medical School, China [n]Anhui Provincial Hospital, China [o]The Affiliated Hospital of Bengbu Medical College, China [p]The First Affiliated Hospital of Sun Yat-sen University, China [q]The Second Hospital of Shanxi Medical University, China [r]Beijing Hospital Affiliated to the Ministry of Health of PRC, China [s]China-Japan Friendship Hospital Affiliated to the Ministry of Health of PRC, China [t]Beijing Chao-Yang Hospital, Capital Medical University, China [u]Xuanwu Hospital Affiliated to Capital Medical University, China [v]Beijing Friendship Hospital Affiliated to Capital Medical University, China [w]Beijing Children Hospital Affiliated to Capital Medical University, China [x]Capital Institute of Pediatrics, China [y]Chinese People's Liberation Army General Hospital, China [z]Changhai Hospital Affiliated to the Second Military Medical University, China [aa]Changzheng Hospital Affiliated to the Second Military Medical University, China [ab]Huashan Hospital Affiliated to Fudan University, China [ac]The First Affiliated Hospital of Anhui Medical University, China [ad]Qilu Hospital of Shandong University, China [ae]The Second Affiliated Hospital of Zhejiang University School of Medicine, China [af]The Third Affiliated Hospital of Sun Yat-sen University, China [ag]The Second Affiliated Hospital of Guangzhou Medical College, China [ah]Guangdong Provincial People's Hospital, China [ai]Xiangya Hospital, Central South University, China [aj]The First Affiliated Hospital of Harbin Medical University, China [ak]The First Hospital of China Medical University, China [al]Xijing Hospital Affiliated to the Fourth Military Medical University, China [am]The Second Hospital of Lanzhou University, China [an]West China Hospital Affiliated to Sichuan University, China [ao]The Affiliated Hospital of North Sichuan Medical College, China [ap]Sichun Provincial People's Hospital, China [aq]The People's Hospital of Xinjiang Autonomous Region, China [ar]Jiangsu Provincial People's Hospital, China [as]The First Affiliated Hospital of Zhengzhou University, China [at]Shengjing Hospital Affiliated to China Medical University, China [au]The First Affiliated Hospital of Shantou University Medical College, China [av]Tianjin First Central Hospital, China [aw]Peking University First Hospital, China [ax]Peking University Shougang Hospital, China [ay]Beijing Jishuitan Hospital, China [az]Fuxing Hospital Affiliated to Capital Medical University, China [ba]Beijing Shunyi Hospital, China [bb]Peking University Third Hospital, China [bc]South-West Hospital Affiliated to Third military Medical University, China [bd]The First People's Hospital of Foshan, China [be]Fujian Provincial Hospital, China [bf]The Second Affiliated Hospital of Fujian Medical University, China [bg]Fuzhou General Hospital of Nanjing Military Region, China [bh]Zhongshan Hospital Affiliated to Fudan University, China [bi]The First Affiliated Hospital of Guangxi Medical University, China [bj]The People's Hospital of Guangxi Autonomous Region, China [bk]The Affiliated Hospital of Guiyang Medical College, China [bl]The Second Affiliated Hospital of Harbin Medical University, China [bm]Hainan Provincial People's Hospital, China [bn]Hebei Provincial People's Hospital, China [bo]Bethune International Peace Hospital, China [bp]Henan Provincial People's Hospital, China [bq]The First Hospital of Qiqihar, China [br]Tongji Hospital Affiliated to Tongji Medical, School of Huazhong University of Science and Technology, China [bs]Jiangxi Provincial People's Hospital, China [bt]No. 202 Hospital of People's Liberation Army, China [bu]The Affiliated Hospital of Inner Mongolia Medical College, China [bv]Nanfang Hospital Affiliated to Southern Medical University, China [bw]The General Hospital of Ningxia Medical University, China [bx]The Affiliated Hospital of Qingdao University Medical College, China [by]The Fourth People's Hospital of Shenzhen Affiliated to Guangdong Medical College, China [bz]The General Hospital of TianJin Medical University, China [ca]Beijing Tongren Hospital Affiliated to Capital Medical University, China [cb]The Second People's Hospital of Wuxi, China [cc]The People's Hospital of Wuxi, China [cd]The Second Xiangya Hospital of Central South University, China [ce]The First People's Hospital of Yunnan Province, China [cf]The First Affiliated Hospital of Zhejiang University School of Medicine, China [cg]Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China [ch]The First People's Hospital of Changzhou, China [ci]The Affiliated Orthopaedic Hospital of Shandong Linyi People's Hospital, China [cj]Zhejiang Provincial People's Hospital, China [ck]The First Affiliated Hospital of Baotou Medical College, China [cl]The Affiliated Hospital of Nantong University, China [cm]The First Affiliated Hospital of Suzhou University, China [cn]Beijing Shijitan Hospital, China [co]Shandong Yantai Yuhuangding Hospital, China [cp]The General Hospital of Daqing Oilfield, China [cq]First Affiliated Hospital of Medical College of Xi'an Jiaotong University, China [cr]Provincial Hospital Affiliated to Shandong University, Jinan, China [cs]Ji'nan University 2nd Clinical Medicine College, Shenzhen People's Hospital, China [ct]No.285 Hospital of People's Liberation Army, China [cu]The First Hospital of Shanxi Medical University, China [cv]Kailuan Hospital Affiliated to North China Coal Medical College, China [cw]Peking University Shenzhen Hospital, China [cx]The First Affiliated Hospital of Fujian Medical University, China [cy]The First Hospital of Ningbo, China [cz]Shanxi Provincial People's Hospital, China [da]The Second Hospital of Hebei Medical University, China [db]The First Affiliated Hospital of Wenzhou Medical College, China [dc]The Third Affiliated Hospital of Hebei Medical University, China [dd]The First Affiliated Hospital of Xinjiang Medical University, China [de]Qingdao Municipal Hospital, China [df]Wuhan Union Hospital Affiliated to Tongji Medical, School of Huazhong University of Science and Technology, China [dg]No. 264 Hospital of People's Liberation Army, China [dh]Zhongda Hospital Affiliated to Southeast University, China [di]The Central Hospital of Sichuan Mianyang, China [dj]The Seventh People's Hospital of Shenyang, China

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关键词： CSTAR Family history Lupus Phenotypes

摘要：

Objective This study aimed to examine the associations between family history and clinical manifestations and immunologic characteristics of lupus in China. Methods Based on their family history, lupus patients from the Chinese Lupus Treatment and Research group (CSTAR) registry were categorised: familial lupus (FL), family history of other rheumatic disorders (RD), and sporadic lupus (SL). Demographic data, clinical manifestations, and laboratory data were compared among these three groups. Results A total of 2,104 patients from CSTAR were included, with 34 (1.6%) in the FL group, 50 (2.4%) in the RD group, and 2,020 (96.0%) in the SL group. There were no significant differences in age or gender among these groups (p=0.36 and p=0.75, respectively). The prevalence of discoid rash and positivity of anti-RNP antibodies differed significantly among the three groups. Photosensitivity and neurological disorder were marginally significantly different among the three groups (p=0.05). No statistical differences were observed in other clinical manifestations or laboratory results. In the FL group, first-degree relatives (25/34, 73.5%) had higher susceptibility to lupus. Rheumatoid arthritis (RA) (35/50, 70.0%) was the most frequent non-lupus rheumatic disorder in the RD group. Conclusion Among lupus patients, the rate of familial lupus was lower in Chinese patients than among other ethnicities. Familial lupus cases are found mainly among their first-degree relatives. A family history of lupus did not significantly affect clinical phenotypes, except for higher frequency of discoid rash and anti-RNP in the FL group, and more anti-RNP positivity in the RD group. © Clinical and Experimental Rheumatology 2018.

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中科院(CAS)分区：

出版当年[2017]版：

大类 | 3 区医学

小类 | 3 区风湿病学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区风湿病学

JCR分区：

出版当年[2016]版：

Q3 RHEUMATOLOGY

最新[2023]版：

Q2 RHEUMATOLOGY

影响因子： 3.4 最新[2023版] 3.1 最新五年平均 2.634 出版当年[2016版] 2.357 出版当年五年平均 2.495 出版前一年[2015版] 3.201 出版后一年[2017版]

第一作者：

第一作者机构： [a]Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China

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Chinese Lupus Treatment and Research group (CSTAR) registry: X. family history in relation to lupus clinical and immunological manifestations

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