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Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients

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资源类型：

收录情况： ◇ SCIE

作者：
Liu, Wei[1] * ; Ling, Shukuan[2] * ; Sun, Weijia[2] ; Liu, Tong[1] ; Li, Yuheng[2] ; Zhong, Guohui[2] ; Zhao, Dingsheng[2] ; Zhang, Pengfei[2] ; Song, Jinping[2] ; Jin, Xiaoyan[2] ; Xu, Zi[2] ; Song, Hailin[2] ; Li, Qi[2] ; Liu, Shujuan[2] ; Chai, Meng[1] ; Dai, Qinyi[3] ; He, Yi[3] ; Fan, Zhanming[3] ; Zhou, Yu Jie[1] ; Li, Yingxian[2] ;
机构： [1]Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University, Beijing, China. [2]State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China. [3]Department of Radiology, Beijing An Zhen Hospital, Capital Medical University, Beijing, China.
出处：
DOI： 10.1038/srep16099
ISSN：

摘要：
The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC), and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary artery disease (CAD) were characterized with coronary artery calcium score (CACS) from cardiac computed tomography (CT). We analyzed plasma miRNA levels of clinical matched 11 CAC (CACS > 100) and 6 non-CAC (CACS = 0) subjects by microarray profile. Microarray analysis identified 34 differentially expressed miRNAs between CAC and non CAC groups. Eight miRNAs (miR-223, miR-3135b, miR-133a-3p, miR-2861, miR-134, miR-191-3p, miR-3679-5p, miR-1229 in CAC patients) were significantly increased in CAC plasma in an independent clinical matched cohort. Four miRNAs (miR-2861, 134, 1229 and 3135b) were correlated with the degree of CAC. Validation test in angiographic cohort showed that miR-134, miR-3135b and miR-2861 were significantly changed in patients with obstructive CAD. We identified three significantly upregulated circulating miRNAs (miR-134, miR-3135b and 2861) correlated with CAC while detected obstructive coronary disease in symptomatic patients.

基金：
National Natural Science Foundation of China Project [31325012, 31271225, 31300698, 81470429, 81100228]; State Key Lab of Space Medicine Fundamentals and Application Grant [SYFD130051833, SYFD140041803]; Beijing Municipal High-Level Talent Foundation of Health System [2011-1-5]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201303]; National Key Clinical specialty Construction Project
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
最新[2023]版：
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
JCR分区：
出版当年[2013]版：
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

第一作者：
第一作者机构： [1]Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University, Beijing, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University, Beijing, China. [2]State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
推荐引用方式(GB/T 7714)：
Liu Wei,Ling Shukuan,Sun Weijia,et al.Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients[J].SCIENTIFIC REPORTS.2015,5:-.doi:10.1038/srep16099.
APA：
Liu, Wei,Ling, Shukuan,Sun, Weijia,Liu, Tong,Li, Yuheng...&Li, Yingxian.(2015).Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients.SCIENTIFIC REPORTS,5,
MLA：
Liu, Wei,et al."Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients".SCIENTIFIC REPORTS 5.(2015):-

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