A prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy
Background Cardiac resynchronization therapy (CRT) with biventricular pacing improves cardiac function, functional capacity and quality of life in selected patients with heart failure. The current study aimed to evaluate the efficacy of the intracardiac electrogram (IEGM)-based optimization method, QuickOpt (TM), in Chinese patients treated with CRT. Methods Aortic time velocity integrals (AVTI) achieved at the sensed atrioventricular (AV), paced AV and interventricular (VV) interval settings recommended by both QuickOpt (TM) and standard echocardiographic optimization were measured in 101 patients. Consistency and the strength of the relationship between the two timing cycle optimization methods were assessed by intra-class correlation coefficient (ICC). Results The ICC showed good agreement and correlation with what the AVTI achieved at the optimal sensed AV (ICC=0.9683 (0.9535-0.9785)), paced AV (ICC=0.9642 (0.9475-0.9757)) and VV (ICC=0.9730 (0.9602-0.9817)) interval settings determined by the two optimization methods. The average time required by echocardiographic optimization and by QuickOpt (TM) were (78.32 +/- 32.40) minutes and (1.98 +/- 1.64) minutes respectively (P<0.0001). Conclusion The QuickOpt (TM) algorithm provides a quicker, simpler and reliable alternative to the standard method for timing cycle optimization. (ClinicalTrial.gov Reference Number: NCT00918294) Chin Med J 2012;125(3):428-433
基金:
St. Jude Medical Inc.St. Jude Medical; China Health & Medical Development Foundation [2008-zhFj1]
第一作者机构:[1]Peking Union Med Coll, Dept Cardiol, Cardiovasc Inst, Beijing 100037, Peoples R China;[2]Chinese Acad Med Sci, Dept Cardiol, Cardiovasc Inst, Beijing 100037, Peoples R China;[3]Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China;
通讯作者:
通讯机构:[1]Peking Union Med Coll, Dept Cardiol, Cardiovasc Inst, Beijing 100037, Peoples R China;[2]Chinese Acad Med Sci, Dept Cardiol, Cardiovasc Inst, Beijing 100037, Peoples R China;[3]Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China;[20]Peking Union Med Coll, Dept Cardiol, Cardiovasc Inst, 167 Beilishi Rd, Beijing 100037, Peoples R China
推荐引用方式(GB/T 7714):
Hua Wei,Wang Dong-mei,Cai Lin,et al.A prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy[J].CHINESE MEDICAL JOURNAL.2012,125(3):428-433.doi:10.3760/cma.j.issn.0366-6999.2012.03.005.
APA:
Hua Wei,Wang Dong-mei,Cai Lin,Sun Chao-feng,Fu Guo-sheng...&Zhang Shu.(2012).A prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy.CHINESE MEDICAL JOURNAL,125,(3)
MLA:
Hua Wei,et al."A prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy".CHINESE MEDICAL JOURNAL 125..3(2012):428-433