机构：[1]Department of Radiology and Department of Neurology, Chinese People’s Liberation Army (PLA), General Hospital, Beijing, China[2]Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA[3]Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for NeurologicalDiseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China重点科室诊疗科室医技科室神经病学中心放射科神经病学中心放射科首都医科大学附属天坛医院[4]Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China[5]Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, CA, USA
The purpose was to assess the difference of collaterals in symptomatic versus asymptomatic patients with unilateral middle cerebral artery (MCA) stenosis by comparing cerebral blood flow (CBF) at two post labeling delays (PLD) using three-dimensional pseudo-continuous arterial spin labeling (3D pCASL). Eighty-one patients (49 symptomatic and 32 asymptomatic) with unilateral MCA stenosis ≥50% who underwent pCASL with two PLDs were included. Mean CBF and CBF subtraction images between two PLDs of MCA territories were compared in symptomatic and asymptomatic groups, respectively. Compared with the asymptomatic group, patients with symptomatic MCA stenosis had significantly lower CBF in the MCA territory of stenotic side at each PLD. The CBF of stenotic territory showed greater increase than that of normal side from PLD 1.5 to 2.5 s. The CBF of asymptomatic MCA territory increased similarly with that of symptomatic MCA territory from PLD of 1.5 to 2.5 s in stenotic side, while symptomatic patients experienced significantly slower antegrade flow. On CBF subtraction images, asymptomatic patients showed larger volume of differences between PLD of 1.5 and 2.5 s compared with those of symptomatic patients ( p = 0.037). The results suggest that more robust collateral perfusion on two-delay 3D pCASL is present in asymptomatic patients compared with symptomatic patients.
基金：
National Key Research and Development Program of China [2016YFC01001004]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81671126, 81471390]
第一作者机构：[1]Department of Radiology and Department of Neurology, Chinese People’s Liberation Army (PLA), General Hospital, Beijing, China[*1]Department of Radiology, Chinese People’s Liberation Army (PLA), General Hospital, 28 Fuxing Road, Beijing 100853, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Radiology and Department of Neurology, Chinese People’s Liberation Army (PLA), General Hospital, Beijing, China[*1]Department of Radiology, Chinese People’s Liberation Army (PLA), General Hospital, 28 Fuxing Road, Beijing 100853, China.
推荐引用方式(GB/T 7714)：
Lou Xin,Ma Xiaoxiao,Liebeskind David S.,et al.Collateral perfusion using arterial spin labeling in symptomatic versus asymptomatic middle cerebral artery stenosis.[J].JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM.2019,39(1):108-117.doi:10.1177/0271678X17725212.
APA：
Lou, Xin,Ma, Xiaoxiao,Liebeskind, David S.,Ma, Ning,Tian, Chenglin...&Wang, Danny J. J..(2019).Collateral perfusion using arterial spin labeling in symptomatic versus asymptomatic middle cerebral artery stenosis..JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,39,(1)
MLA：
Lou, Xin,et al."Collateral perfusion using arterial spin labeling in symptomatic versus asymptomatic middle cerebral artery stenosis.".JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 39..1(2019):108-117
医学