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Evaluation of the therapeutic effects of QuickOpt optimization in Chinese patients with chronic heart failure treated by cardiac resynchronization

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机构： [1]Department of Cardiology, Anhui Provincial Hospital, No. 17 Lujiang Road, Hefei, 230001, China. [2]Cardiac Arrhythmia center, Fuwai Hospital, Chinese Academy of medical Sciences, No. 167 North Lishi Road, Beijing, 100037, China. [3]Department of Cardiology, West China Hospital, Sichuan University, No. 37 Guoxue lane, Chengdu, 610041, China. [4]Department of Cardiology, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an, 710061, China. [5]Department of Cardiology, Tianjin chest hospital, No. 93 Xi’an Road, Tianjin, 300051, China. [6]Department of Cardiology, The First Affiliated Hospital, Zhejiang University, No. 79 Qingchun Road, Hangzhou, 310003, China. [7]Department of Cardiology, The General Hospital of Lanzhou Military, No. 98 Xiaoxihu West Street, Lanzhou, 730050, China. [8]Department of Cardiology, The First Hospital of Lanzhou University, No. 1 Donggang West Road, Lanzhou, 730000, China. [9]Department of Cardiology, The General Hospital of Shenyang Military, No. 83 Wenhua Road, Shenyang, 110840, China. [10]Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, No. 137 Liyushan South Road, Urumqi, 830054, China. [11]Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, China. [12]Department of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, China. [13]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Beijing, 100029, China. [14]Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, No. 107 Yanjiang West Road, Guangzhou, 510120, China. [15]Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Kunming, 650032, China. [16]Department of Cardiology, General Hospital of Ningxia Medical University, No. 804 Shengli South Street, Yinchuan, 750004, China. [17]Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, No. 58 Zhongshan Er Road, Guangzhou, 510080, China. [18]Department of Cardiology, Renmin Hospital of Wuhan University, No. 99 Zhangzhidong Road, Wuhan, 430060, China. [19]Department of Cardiology, Sir Run Run Shaw Hospital of Medicine, Zhejiang University, No. 3 Qingchun East Road, Hangzhou, 310020, China. [20]Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanjing, 530021, China. [21]Department of Cardiology, Fujian Provincial Hospital, No. 134 East Street, Fuzhou, 350001, China. [22]The First Department of Cardiology, The 251ST Hospital of PLA, No. 13 Jianguo Road, Zhangjiakou, 075000, China. [23]Department of Cardiology, Hangzhou First People’s Hospital, No. 261 HuanSha Road, Hangzhou, 310006, China. [24]Department of Cardiology, The second people’s Hospital of Yunnan Province, No. 176 Qingnian Road, Kunming, 650021, China. [25]Department of Cardiology, Hebei General Hospital, No. 348 Heping West Road, Shijiazhuang, 050051, China. [26]Department of Cardiology, People’s Hospital of Yuxi City, No. 21 Nieer Road, Yuxi, 653100, China. [27]Department of Cardiology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing, 100853, China. [28]Department of Cardiology, Xiangya Hospital Central South University, No. 87 xiangya Road, Changsha, 410008, China. [29]Department of Cardiology, Zhejiang Greentown Hospital, No. 409 Gudun Road, Hangzhou, 310000, China. [30]Department of Cardiology, The Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Tianjin, 300211, China. [31]Department of Cardiology, Daqing Oilfield General Hospital, No. 9 Zhongkang Street, Daqing, 163000, China. [32]Department of Cardiology, Shaoxing People’s Hospital, No. 568 Zhongxing North Road, Shaoxing, 312000, China.

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In this trial, long-term therapeutic effects and clinical improvements in Chinese chronic heart failure patients optimized by QuickOpt or echocardiography were compared for atrioventricular (AV) and interventricular (VV) delay optimizations after cardiac resynchronization therapy (CRT) with pacing (CRT-P) or with pacing and defibrillator (CRT-D) therapy. One hundred and ninety-six subjects (50%) had dilated cardiomyopathy, 108 (27.6%) had ischemic heart disease and 112 (28.6%) were hypertensive and were randomized into QuickOpt (198) or echocardiographic optimization (control) (194) groups at <= 2-weeks post-implantation. Programmed AV/VV delay was optimized at baseline and at 3 and 6 months. Left ventricular end-systolic volume (LVESV), New York Heart Association (NYHA) class, specific activity scale (SAS), and the six-minute walk tests (6MWT) were evaluated by blinded researchers at 12 months. Of the QuickOpt group, LVESV decreased significantly by 24.7% +/- 33.9% compared with baseline, while LVESV of Controls decreased by 25.1% +/- 36.1% (P = 0.924). NYHA class, SAS and 6MWT also improved similarly in both groups at 12 months. Mortality in both groups was not significantly different (11.0% vs 7.6%, P = 0.289). However, there was a significant difference in the time required for optimization by QuickOpt compared with echocardiography (3.33 +/- 3.11 vs 58.79 +/- 27.03 minutes, P < 0.000).

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出版当年[2017]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

最新[2023]版：

大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

第一作者：

第一作者机构： [1]Department of Cardiology, Anhui Provincial Hospital, No. 17 Lujiang Road, Hefei, 230001, China.

通讯作者：

通讯机构： [2]Cardiac Arrhythmia center, Fuwai Hospital, Chinese Academy of medical Sciences, No. 167 North Lishi Road, Beijing, 100037, China. [3]Department of Cardiology, West China Hospital, Sichuan University, No. 37 Guoxue lane, Chengdu, 610041, China.

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