机构：[1]Beijing Neurosurgical Institute, Beijing 100050, China.研究所北京市神经外科研究所首都医科大学附属天坛医院[2]School of Medicine, Tsinghua University, Beijing 100084, China.[3]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[4]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215123, China.神经外科普外科苏州大学附属第二医院[5]Centre of Brain Tumour, Beijing Institute for Brain Disorders, Beijing 100069, China.[6]China National Clinical Research Centre for Neurological Diseases, Beijing 100050, China.
Gliomas are the most common and lethal intracranial tumours. RNA sequencing technologies and advanced data analyses recently enabled the characterization of transcriptomic information, including protein-coding gene expression, non-coding gene expression, alternative splicing, and fusion gene detection, to facilitate detection of diseases and altered phenotypes. As a part of the Chinese Glioma Genome Atlas (CGGA) project, our aim was to delineate comprehensive transcriptome profiling in the malignant progression of human gliomas. Three hundred twenty five gliomas with different grades were collected over the past twelve years. Using the Illumina HiSeq 2,000 system, over 92 million high quality 101-bp paired-end reads were generated per sample, yielding a total of 30 billion reads. This comprehensive dataset will be useful to deepen the comprehensive understanding of gliomas, providing an opportunity to generate new therapies, diagnoses, and preventive strategies.
基金：
This work was supported by The National Key Research and Development Plan
(No. 2016YFC0902500).
第一作者机构：[1]Beijing Neurosurgical Institute, Beijing 100050, China.
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Neurosurgical Institute, Beijing 100050, China.[3]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.[5]Centre of Brain Tumour, Beijing Institute for Brain Disorders, Beijing 100069, China.[6]China National Clinical Research Centre for Neurological Diseases, Beijing 100050, China.
推荐引用方式(GB/T 7714)：
Zheng Zhao,Fanlin Meng,Wen Wang,et al.Comprehensive RNA-seq transcriptomic profiling in the malignant progression of gliomas[J].SCIENTIFIC DATA.2017,4:-.doi:10.1038/sdata.2017.24.
APA：
Zheng Zhao,Fanlin Meng,Wen Wang,Zheng Wang,Chuanbao Zhang&Tao Jiang.(2017).Comprehensive RNA-seq transcriptomic profiling in the malignant progression of gliomas.SCIENTIFIC DATA,4,
MLA：
Zheng Zhao,et al."Comprehensive RNA-seq transcriptomic profiling in the malignant progression of gliomas".SCIENTIFIC DATA 4.(2017):-
