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Relationship between Blood Pressure and Outcomes in Acute Ischemic Stroke Patients Administered Lytic Medication in the TIMSChina Study

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机构： [a]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [b]Department of Neurology, Qilu Hospital of Shandong University, Jinan China and Braian Science Research Institute, Shandong University, Jinan, China [c]Beijing Tiantan Hospital, China [d]Beijing Anzhen Hospital, China [e]Peking Union Medical College Hospital of Peking University, China [f]Beijing Jishuitan Hospital, China [g]Beijing Shijitan Hospital, China [h]Peking University Third Hospital, China [i]Beijing Tongren Hospital, China [j]Shanghai Renji Hospital, China [k]Shanghai First Municipal People's Branch Hospital, China [l]Zhongshan Hospital of Fudan University, China [m]Fifth People's Hodpital of Shanghai, Fudan University, China [n]Xin Hua Hospital Affiliated, Shanghai Jiao Tong University, China [o]Sixth People's Hospital Affiliated, Shanghai JiaoTong University, China [p]Shanghai 8th People's Hospital, China [q]Pudong New Area People's Hospital, China [r]Shanghai Yangpu Area Shidong Hospital, China [s]Shanghai Baoshan Area Center Hospital, China [t]Shanghai Yangpu Area Center Hospital, China [u]Huashan Hospital of Fudan University, China [v]Tianjin Medical University Gengeal Hospital, China [w]Dagang Oilfield Gengeal Hospital, China [x]Tianjin Fifth Center Hospital, China [y]Bohai Oilfield Hospital, China [z]Ninghe County People's Hospital of Tianjin, China [aa]Baodi District People's Hospital of Tianjin, China [ab]First Afflicated Hospital of Dlian Medical University, China [ac]Dalian Second People's Hospital, China [ad]Dalian Third People's Hospital, China [ae]Dalian Central Hospital, China [af]Dalian Economic and Technological Development District Hospital, China [ag]Shenying Military District General Hospital of Chinese People's Liberation Army, China [ah]National Traditional Chinese Medicine (TCM) Thrombus Treatment Center of Liaoning Province, China [ai]Jilin Chemical Industrial Group General Hopital, China [aj]Jilin Oilfield General Hospital, China [ak]First Clinical College of Harbin Medical University, China [al]Second Clinical College of Harbin Medical University, China [am]Fourth Clinical College of Harbin Medical University, China [an]Mudan Jiang Second Hospital, China [ao]Shaanxi Provincial People's Hospital, China [ap]First Hospital of Xiamen, China [aq]Hunan Provincial People's Hospital, China [ar]Chenzhou First People's Hospital, China [as]Xiangya Hospital of Centre-south University, China [at]Southwest Hospital, China [au]Chengdu Third Municipal People's Hospital, China [av]First Affiliated Hospital of Jinan University, China [aw]First Affiliated Hospital of Guangzhou Medical University, China [ax]Second Affiliated Hospital of Guangzhou Medical University, China [ay]Guangzhou First Municipal People's Hospital, China [az]Guangdong Provincial Hospital of Traditional Chinese Medicine, China [ba]Drum Tower Hospital Affiliated, Nanjing Medical University, China [bb]Affiliated Hospital of Nantong University, China [bc]Wuxi Second People's Hospital, China [bd]Third Affiliated Hospital of Suzhou University, China [be]Tangshan Gongren Hospital, China [bf]Zhongnan Hospital of Wuhan University, China [bg]Hubei Xinhua Hospital, China [bh]Qingdao Municipal Hospital Group, China [bi]Dezhou People's Hospital, China [bj]Penglai People's Hospital, China [bk]First Affiliated Hospital of Wenzhou Medical University, China [bl]First People's Hospital of Yunnan Province, China [bm]Xinjiang Autonomous Region People's Hospital, China [bn]Autonomous Region TCM Hospital Affiliated, Xinjiang Medical University, China [bo]Hospital of Xinjiang Production and Construction Corps, China [bp]Qinghai Provincial People's Hospital, China [bq]Yangquan Coalmine Group General Hospital, China

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Objective Increased blood pressure (BP) management following acute ischemic stroke (AIS) remains controversial. This study aimed to identify the association between BP and clinical outcomes in AIS patients administered lytic medication in the TIMS-China (thrombolysis implementation and monitor of acute ischemic stroke in China) database. Methods The sample comprised 1128 patients hospitalized within 4.5 hours (h) of AIS for intravenous recombinant tissue plasminogen activator (i.v. rt-PA) thrombolysis. Systolic BP (SBP) and diastolic BP (DBP) at baseline, 2 h and 24 h after treatment, and changes from baseline were analyzed. The study outcomes comprised a favorable outcome (modified Rankin Scale 0-1 at 90 days) and symptomatic intracerebral hemorrhage (SICH), analyzed using logistic regression, with low BP as the reference group. Results Lower BP (baseline, 2 h, and 24 h) was beneficial in AIS patients and significantly related to a favorable outcome (Poutcome (P<0.05). A substantial BP decrease at 24 h after rt-PA thrombolysis was significantly associated with a favorable outcome compared with a moderate BP decrease (P = 0.0298). A SBP >160 mmHg 2 h after rt-PA thrombolysis was significantly associated with SICH compared with a SBP <140 mmHg (P = 0.0238). An increase or no change (>25 mmHg) in SBP was significantly associated with SICH (P = 0.002) compared with a small SBP decrease (1-9 mmHg). © 2016 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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出版当年[2015]版：

大类 | 3 区生物

小类 | 3 区综合性期刊

最新[2023]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

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出版当年[2014]版：

Q1 MULTIDISCIPLINARY SCIENCES

最新[2023]版：

Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 2.9 最新[2023版] 3.3 最新五年平均 3.234 出版当年[2014版] 3.702 出版当年五年平均 3.534 出版前一年[2013版] 3.057 出版后一年[2015版]

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