机构：[1]Beijing Neurosurgical Institute, Capital Medical University, Beijing, China研究所北京市神经外科研究所首都医科大学附属天坛医院[2]Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室医技科室放射科放射科首都医科大学附属天坛医院
Background: Brain arteriovenous malformation (bAVM)-related epilepsy can significantly affect patient quality of life. We aimed to identify the factors associated with seizures occurrence and evaluate the long-term outcome following Onyx embolization in bAVM patients. Methods: Between July 2014 and July 2016, 239 consecutive patients underwent treatment for bAVMs in our institute and were respectively analyzed. Demographics, seizure status and bAVM morphologic characteristics were recorded. Modified Engel classification was used to evaluate the long-term seizure outcomes. Results: Of 239 bAVM patients, 68 (28.5%) initially presented with seizures. Seizure occurrence was associated with cerebral hemorrhage history, frontal-temporal location and arterial borderzone location. Of the 37 patients who presented with initial seizures and were treated with Onyx embolization, 23 (62.2%) were treated with antiepileptic drugs (AEDs) before Onyx embolization. At the last follow-up visit, 19 (51.4%) of the 37 patients reached modified Engel class I outcome. Of the 23 patients who had ever been treated with AEDs, 12 (52.2%) were still taking AEDs at the last follow-up visit. Single-factor analysis showed that arterial borderzone location was significantly correlated with higher modified Engel class outcome (p = 0.046). Conclusion: Patients with bAVM hemorrhage history, frontal-temporal location and arterial borderzone location were associated with seizure occurrence. Seizure-free status was not obtained in AVM patients with arterial borderzone after embolization, though it may have benefits in other ways. The seizure-free mechanism of bAVM with Onyx embolization is worth further study.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81771233]; Specific Research Projects for Capital Health Development [2018-2-2041]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|4 区临床神经病学4 区核医学
最新[2023]版：
大类|4 区医学
小类|4 区临床神经病学4 区核医学
JCR分区：
出版当年[2017]版：
Q4RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ4CLINICAL NEUROLOGY
最新[2023]版：
Q3CLINICAL NEUROLOGYQ3RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ4CLINICAL NEUROLOGY
第一作者机构：[1]Beijing Neurosurgical Institute, Capital Medical University, Beijing, China[2]Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Neurosurgical Institute, Capital Medical University, Beijing, China[2]Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[*1]Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, No. 6, Tiantan Xili, Dongcheng District, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Zhang Baorui,Feng Xin,Peng Fei,et al.Seizure predictors and outcome after Onyx embolization in patients with brain arteriovenous malformations[J].INTERVENTIONAL NEURORADIOLOGY.2019,25(2):124-131.doi:10.1177/1591019918801290.
APA：
Zhang, Baorui,Feng, Xin,Peng, Fei,Wang, Luyao,Guo, Er Kang...&Liu, Aihua.(2019).Seizure predictors and outcome after Onyx embolization in patients with brain arteriovenous malformations.INTERVENTIONAL NEURORADIOLOGY,25,(2)
MLA：
Zhang, Baorui,et al."Seizure predictors and outcome after Onyx embolization in patients with brain arteriovenous malformations".INTERVENTIONAL NEURORADIOLOGY 25..2(2019):124-131
