机构：[a]Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China[b]Department of Neurosurgery, The Second People's Hospital of Hunan Province, The Hospital of Hunan University of Chinese Medicine, Changsha, China[c]Department of Neurosurgery, The Central Hospital of Shaoyang, Shaoyang, China[d]Department of Neurosurgery, Yiyang Central Hospital, Yiyang, China[e]Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[f]Department of Psychiatry, The Second People's Hospital of Hunan Province, The Hospital of Hunan University of Chinese Medicine, Changsha, China[g]Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China
Background: A pseudogene is a gene copy that has lost its original coding ability. Pseudogenes participate in numerous biological processes including oncogenesis. Objectives: We screened for prognostic pseudogenes for lower-grade glioma (LGG) and explored the potential molecular mechanisms. Methods: LGG data downloaded from The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA) databases were used as training and validation dataset, respectively. Univariate Cox proportional hazard regression was performed to identify pseudogenes with significant prognostic value. Robust likelihood-based survival model and LASSO regression were performed to screen for the most survival-relevant pseudogenes. A risk score model was constructed based on the prognostic pseudogenes to predict the prognosis of LGG patients. Results: Five pseudogenes (PKMP3, AC027612.4, HILS1, RP5-1132H15.3 and HSPB1P1) were identified as prognostic gene-signatures. Using the risk score model established based on the five pseudogenes, LGG patients were stratified into distinct prognosis groups in both TCGA and CGGA datasets (P < 0.0001). Univariate and multivariate Cox regression analyses confirmed that the risk score generated from the model was an independent prognostic factor in LGG patients (p < 0.05). Furthermore, functional analysis revealed the potential biological mechanisms mediated by the five prognostic pseudogenes. Conclusions: Five novel pseudogenes capable of predicting survival in LGG patients were identified. Our findings provide novel insights into the biological role of pseudogenes in LGG.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81703622]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M633002]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2018JJ3838]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区药学
最新[2023]版：
大类|2 区医学
小类|1 区药学2 区医学：研究与实验
JCR分区：
出版当年[2017]版：
Q2PHARMACOLOGY & PHARMACYQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[a]Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
通讯作者：
通讯机构：[a]Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China[g]Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China[*1]Department of Neurosurgery & Department of Clinical Pharmacology Xiangya Hospital, Central South University Add: No.87 Xiangya Rd., Kaifu District, Changsha, 410008, Hunan, China.
推荐引用方式(GB/T 7714)：
Bo Liu,Jingping Liu,Kun Liu,et al.A prognostic signature of five pseudogenes for predicting lower-grade gliomas[J].BIOMEDICINE & PHARMACOTHERAPY.2019,117:-.doi:10.1016/j.biopha.2019.109116.
APA：
Bo Liu,Jingping Liu,Kun Liu,Hao Huang,Yexin Li...&Quan Cheng.(2019).A prognostic signature of five pseudogenes for predicting lower-grade gliomas.BIOMEDICINE & PHARMACOTHERAPY,117,
MLA：
Bo Liu,et al."A prognostic signature of five pseudogenes for predicting lower-grade gliomas".BIOMEDICINE & PHARMACOTHERAPY 117.(2019):-
医学