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Higher risk of deep vein thrombosis after hemorrhagic stroke than after acute ischemic stroke

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机构： [1]Department of Neurology, Tiantan Hospital, Capital Medical University, Beijing, China [2]China National Clinical Research Center for Neurological Diseases, Beijing, China [3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China [4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China [5]Beijing Key Laboratory of Brain Function Restoration, Beijing, China.

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Patients with stroke are at particularly increased risk of developing deep vein thrombosis (DVT) during hospitalization. In this study, we aimed to compare the potential risk of in-hospital DVT by stroke subtypes. This study is based on a prospective cohort (in-hospital medical complication after acute stroke [iMCAS] registry) enrolling patients with acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH). In-hospital DVT was diagnosed by clinical manifestations and verified by compression Doppler ultrasound. A logistic regression analysis was performed to assess the association between stroke subtypes and occurrence of DVT. A total number of 1,771 patients were enrolled in the iMCAS. The mean age was 57.1 +/- 12.9 years, and 27.5% were female patients. The median length of stay was 14 days (interquartile range [IQR], 11-16). The median National Institutes of Health Stroke Scale score on admission for patients with AIS, ICH, and SAH was 4 (IQR: 2-8), 4 (IQR: 1-10), and 0 (IQR: 0-0), respectively. In-hospital DVT after AIS, ICH, and SAH was 1.9%, 5.7%, and 7.9%, respectively. The median time from stroke onset to DVT formation after AIS, ICH, and SAH was 10.5 days (IQR: 3.8-14.5), 7.5 days (IQR: 4.0-9.5), and 7.0 days (IQR: 5.0-12.5), respectively. After adjusting for potential confounders, patients with ICH (odds ratio = 7.350; 95% confidence interval = 2.411-22.13; P < .001) and SAH (odds ratio = 11.92; 95% confidence interval = 5.192-27.38; P < .001) had significantly higher risk of in-hospital DVT than those patients with AIS. In conclusion, patients with hemorrhagic stroke (ICH and SAH) have significantly higher risk of in-hospital DVT than patients with AIS. Further studies on pathophysiologic mechanisms are warranted.

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第一作者：

第一作者机构： [1]Department of Neurology, Tiantan Hospital, Capital Medical University, Beijing, China [2]China National Clinical Research Center for Neurological Diseases, Beijing, China [3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China [4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China [5]Beijing Key Laboratory of Brain Function Restoration, Beijing, China. [*1]Beijing Tiantan Hospital, Capital Medical University, No.6 Tiantanxili, Dongcheng District, Beijing 100050, China.

通讯作者：

通讯机构： [1]Department of Neurology, Tiantan Hospital, Capital Medical University, Beijing, China [2]China National Clinical Research Center for Neurological Diseases, Beijing, China [3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China [4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China [5]Beijing Key Laboratory of Brain Function Restoration, Beijing, China. [*1]Beijing Tiantan Hospital, Capital Medical University, No.6 Tiantanxili, Dongcheng District, Beijing 100050, China.

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