机构:[1]Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.外科系统浙江大学医学院附属第一医院[2]Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, China.[3]Department of Pediatrics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.内科系统儿科浙江大学医学院附属第一医院[4]Department of Endocrinology, Chongqing Medical University Affiliated Children’s Hospital, Chongqing, China.[5]Department of Pediatrics, Tianjin Medical University General Hospital, Tianjin, China.[6]Department of Pediatrics, Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing, China.临床科室新生儿中心首都医科大学附属北京儿童医院[7]Department of Pediatric Endocrinology and Genetic Metabolic Diseases, Children’s Hospital of Fudan University, Shanghai, China.[8]Department of Pediatrics Endocrinology, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
BackgroundThe relationship between birth weight and blood pressure has not been well explored in Chinese children and adolescents. The aim of this study was to investigate the relationship between birth weight and childhood blood pressure in China.MethodsA total of 15324 children and adolescents (7919 boys and 7405 girls) aged 7-17years were stratified into six birth weight groups. Analysis of covariance and binary logistic regression were used to analyse the relationship between birth weight and blood pressure while controlling for potential confounding factors, including age, gestational age, season of birth and area of residence.ResultsThe group with birth weights from 2500 to 2999g had the lowest prevalence of hypertension (8.9%). Lower birth weight children (< 2000g) had significantly higher systolic blood pressure (SBP) (106.000.72, P=0.017), and children with heavier birth weights also had higher SBP (3500-3999g, 105.13 +/- 0.17, P<.001; >= 4000g, 105.96 +/- 0.27, P<.001). No significant relationship was found between birth weight and diastolic blood pressure (DBP). The overall rate of hypertension was 10.8% (12.1% in boys and 9.4% in girls). The median weight group (2500-2999g) had the lowest rate of hypertension (8.9%). Compared with children in the median weight group, children with lower birth weight had a higher prevalence of hypertension (< 2000g, OR=1.85, 95% CI=1.25-2.74; 2000-2499g, OR=1.57, 95% CI=1.15-2.13), and groups with higher birth weights also had higher risks of hypertension (3500-3999g, OR=1.22, 95% CI=1.02-1.45; >= 4000g, OR=1.42, 95% CI=1.16-1.74).Conclusions p id=Par4 Excluding the confounding effect of obesity, a U-shaped relationship between birth weight and risk of hypertension was found in children and adolescents in Chinese cities. Birth weight significantly influences SBP but has a minimal effect on DBP. Further basic research on foetal development and programming may shed light on this phenomenon.
基金:
National Key Technology R&D Program of ChinaNational Key Technology R&D Program [2017YFC0907004, 2012BAI02B03, 2009BAI80B02]; Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents