机构：[1]Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,重点科室医技科室研究所放射科放射科北京市神经外科研究所首都医科大学附属天坛医院[2]Beijing Neurointerventional Engineering Center, Beijing, China
Background: Bifurcation and sidewall aneurysms have different rupture risks, but whether this difference comes from the location of the aneurysm is not clear. The objective of this study is to illustrate the rationality of ranking bifurcation configuration as an independent risk factor for aneurysm rupture. Methods: Morphological features of 719 aneurysms (216 ruptured) were automatically extracted from a consecutive cohort of patients via PyRadiomics. Rupture risks and morphological features were compared between bifurcation and sidewall aneurysms, and lasso regression was applied to explore the morphological determinants for rupture in bifurcation and sidewall aneurysms. Rupture risks and morphological features of bifurcation aneurysms in different locations were analyzed. Multivariate regression was performed to explore the risk factors for aneurysm rupture. Results: Twelve morphological features were automatically extracted from PyRadiomics implemented in Python. The rupture risks were higher in bifurcation aneurysms (P < 0.01), and morphological features Elongation and Flatness were much lower in ruptured bifurcation than sidewall aneurysms (P = 0.036, 0.011, respectively). Elongation and Flatness were the morphological determinants for rupture in bifurcation aneurysms, whereas Elongation and SphericalDisproportion were determinants for sidewall aneurysms. Different rupture risks and morphological features were found between sidewall and bifurcation aneurysms of the same location, and among bifurcation aneurysms of different locations. In multivariate regression, bifurcation configuration was an independent risk factor for aneurysm rupture (OR 3.007, 95% CI 1.752-5.248, P < 0.001). Conclusions: Sidewall and bifurcation aneurysms and bifurcation aneurysms of different locations have different rupture risks and morphological features. Bifurcation configuration is an independent risk factor for aneurysm rupture irrespective of location.
基金：
National Key Research and Development Program of China [2017YFB1304400]
第一作者机构：[1]Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,[2]Beijing Neurointerventional Engineering Center, Beijing, China
通讯作者：
通讯机构：[1]Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,[2]Beijing Neurointerventional Engineering Center, Beijing, China
推荐引用方式(GB/T 7714)：
Qinglin Liu,Peng Jiang,Yuhua Jiang,et al.Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location[J].FRONTIERS IN NEUROLOGY.2019,10(JUL):-.doi:10.3389/fneur.2019.00844.
APA：
Qinglin Liu,Peng Jiang,Yuhua Jiang,Shaolin Li,Huijian Ge...&Youxiang Li.(2019).Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location.FRONTIERS IN NEUROLOGY,10,(JUL)
MLA：
Qinglin Liu,et al."Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location".FRONTIERS IN NEUROLOGY 10..JUL(2019):-
