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Cell Counts, rather than Proportion, of CD8/PD-1 Tumor-Infiltrating Lymphocytes in a Tumor Microenvironment Associated with Pathological Characteristics of Chinese Invasive Ductal Breast Cancer

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收录情况： ◇ SCIE

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机构： [1]Department of Science and Technology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China [2]Beijing Key Laboratory of Cancer Therapeutic Vaccines, Beijing 100038, China [3]Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China [4]University of the Incarnate Word, San Antonio, TX 78209, USA [5]Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China [6]Department of Medical Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China [7]Sid Faithfull Brain Cancer Research Laboratory, QIMR Berghofer Medical Research Institute, Locked Bag 2000 Royal Brisbane Hospital, QLD 4029, Australia [8]Department of Infection Control, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China [9]Department of Cancer Research, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China

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Objective. This study is aimed at investigating the association of exhausted CD8(+) tumor-infiltrating lymphocytes with clinic-pathological factors. Methods. 133 patients diagnosed with primary invasive ductal breast cancer were recruited into the cross-sectional study consecutively. Immunohistochemistry was used to detect biomarker expression on formalin-fixed and paraffin-embedded sections. Double staining of CD8 and PD-1 was conducted on lymphocytes. Results. The proportion of CD8(+)/PD-1(-) TILs was 16% among patients with axillary lymph node metastasis, significantly lower than those without metastasis (24%). The expression of CK7, CK20, or Ki-67 was not related with the proportion of phenotypes of CD8/PD-1 TILs. Younger patients had more cell counts of CD8(+)/PD-1(-) TILs than elderly patients (18/HPF vs. 9/HPF, p<0.05). Patients with axillary lymph node metastasis had less CD8(+)/PD-1(-) TILs than those without metastasis (11/HPF vs. 27/HPF, p<0.05). Median counts of CD8(+)/PD-1(-) TILs among patients with CK20 and E-Cad expression were 33/HPF and 14/HPF, significantly higher than those among patients with negative CK20 (16/HPF) and E-Cad expression (6/HPF). Ki-67 index had a significant correlation with cell counts of CD8(+)/PD-1(+) TILs and CD8(+)/PD-1(-) TILs, and the correlation coefficients were 0.19 and 0.21 (p<0.05), respectively. Conclusion. The proportion of CD8(+)/PD-1(-) TILs was related with metastatic status of the axillary lymph node but cell counts of CD8(+)/PD-1(-) TILs were related with metastatic status of the axillary lymph node and expression of CK7, CK20, E-Cad, and Ki-67. Absolute cell counts, not proportion of CD8/PD-1 TILs, were more likely to distinguish clinic and pathologic characteristics of breast cancer.

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出版当年[2018]版：

大类 | 3 区医学

小类 | 3 区免疫学

最新[2023]版：

大类 | 3 区医学

小类 | 4 区免疫学

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出版当年[2017]版：

Q2 IMMUNOLOGY

最新[2023]版：

Q2 IMMUNOLOGY

影响因子： 3.5 最新[2023版] 4.2 最新五年平均 3.298 出版当年[2017版] 3.562 出版当年五年平均 3.276 出版前一年[2016版] 3.404 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Science and Technology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China [2]Beijing Key Laboratory of Cancer Therapeutic Vaccines, Beijing 100038, China

通讯作者：

通讯机构： [1]Department of Science and Technology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China [2]Beijing Key Laboratory of Cancer Therapeutic Vaccines, Beijing 100038, China

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