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Cystatin C and risk of new-onset depressive symptoms among individuals with a normal creatinine-based estimated glomerular filtration rate: A prospective cohort study

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机构: [a]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China [b]Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China [c]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [d]Guanghua Group Pty Ltd, Melbourne, Victoria, Australia [e]Department of Mathematics and Statistics, La Trobe University, Melbourne, Victoria, Australia [f]Global Health and Genomics, School of Medical Sciences and Health, Edith Cowan University, Perth, Western Australia, Australia [g]Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
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关键词: Cystatin C Renal function Depressive symptoms Elderly

摘要:
The association between cystatin C and depressive symptoms in the general population has not been thoroughly elucidated to date. We investigated the association of cystatin C with new-onset depressive symptoms among individuals with normal creatinine-based estimated glomerular filtration rates (eGFR). In the China Health and Retirement Longitudinal Study, 5111 participants without depressive symptoms or renal dysfunction (eGFR < 60 ml/min/1.73 m(2)) were included. The outcome was new-onset depressive symptoms over 4 years, defined as a score of >= 12 on the 10-item Center for Epidemiologic Studies Depressive Symptoms Scale. The incidence risk ratio (IRR) and 95% confidence interval (CI) were calculated using modified Poisson regression models. During a 4-year follow-up period, 1746 (34.16%) incidents of depressive symptoms occurred. In a multivariable-adjusted model, the risk of incident depressive symptoms was 1.07 (95% CI 1.02-1.11) per-SD change in cystatin C. A greater cystatin C level was associated with a higher risk of new-onset depressive symptoms among subjects with relatively normal renal function.

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出版当年[2018]版:
大类 | 3 区 医学
小类 | 4 区 精神病学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 精神病学
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出版当年[2017]版:
Q2 PSYCHIATRY Q3 PSYCHIATRY
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Q1 PSYCHIATRY

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第一作者机构: [a]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China [b]Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China
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通讯机构: [a]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China [b]Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China [*1]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No.10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing 100069, China.
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