Cystatin C and risk of new-onset depressive symptoms among individuals with a normal creatinine-based estimated glomerular filtration rate: A prospective cohort study
机构:[a]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China[b]Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China[c]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[d]Guanghua Group Pty Ltd, Melbourne, Victoria, Australia[e]Department of Mathematics and Statistics, La Trobe University, Melbourne, Victoria, Australia[f]Global Health and Genomics, School of Medical Sciences and Health, Edith Cowan University, Perth, Western Australia, Australia[g]Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
The association between cystatin C and depressive symptoms in the general population has not been thoroughly elucidated to date. We investigated the association of cystatin C with new-onset depressive symptoms among individuals with normal creatinine-based estimated glomerular filtration rates (eGFR). In the China Health and Retirement Longitudinal Study, 5111 participants without depressive symptoms or renal dysfunction (eGFR < 60 ml/min/1.73 m(2)) were included. The outcome was new-onset depressive symptoms over 4 years, defined as a score of >= 12 on the 10-item Center for Epidemiologic Studies Depressive Symptoms Scale. The incidence risk ratio (IRR) and 95% confidence interval (CI) were calculated using modified Poisson regression models. During a 4-year follow-up period, 1746 (34.16%) incidents of depressive symptoms occurred. In a multivariable-adjusted model, the risk of incident depressive symptoms was 1.07 (95% CI 1.02-1.11) per-SD change in cystatin C. A greater cystatin C level was associated with a higher risk of new-onset depressive symptoms among subjects with relatively normal renal function.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81530087]
第一作者机构:[a]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China[b]Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China
通讯作者:
通讯机构:[a]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China[b]Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China[*1]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No.10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing 100069, China.
推荐引用方式(GB/T 7714):
Li Haibin,Wang Anxin,Qi Gao,et al.Cystatin C and risk of new-onset depressive symptoms among individuals with a normal creatinine-based estimated glomerular filtration rate: A prospective cohort study[J].PSYCHIATRY RESEARCH.2019,273:75-81.doi:10.1016/j.psychres.2019.01.009.
APA:
Li Haibin,Wang Anxin,Qi Gao,Guo Jin,Li Xia...&Guo Xiuhua.(2019).Cystatin C and risk of new-onset depressive symptoms among individuals with a normal creatinine-based estimated glomerular filtration rate: A prospective cohort study.PSYCHIATRY RESEARCH,273,
MLA:
Li Haibin,et al."Cystatin C and risk of new-onset depressive symptoms among individuals with a normal creatinine-based estimated glomerular filtration rate: A prospective cohort study".PSYCHIATRY RESEARCH 273.(2019):75-81