机构：[a]Cardiovascular Surgery II, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China临床科室职能科室临床流行病与循证医学中心心脏外科首都医科大学附属北京儿童医院[b]The Heart Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China[c]Pediatric Heart Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China临床科室小儿心脏中心首都医科大学附属安贞医院
Background: Platelet parameters play an important role in thrombosis. This study investigates the role of platelet parameters in the occlusion of modified Blalock Taussig (BT). Objectives: To investigate the association between mean platelet volume (MPV), platelet distribution width (PDW) and BT conduit obstruction and to evaluate the role of MPV and PDW in BT conduit obstruction. Methods: 388 patients with modified BT shunt in the Pediatric Heart Center, Anzhen Hospital From January 1, 2008 to December 30, 2014 were divided into BT obstruction group (OBS) 11 cases and BT non-obstruction group (N-OBS) 377 cases according to whether the BT tube was occluded. The platelet count, mean platelet volume and platelet distribution width in the both groups were measured. The BT pipe occlusion related risk factors were analyzed. Results: There was no significant difference in PC value of OBS group [(221 +/- 28.4) x 109/L] and that of N-OBS group [(198 +/- 69.1) x 109/L). MPV [(15 +/- 6.8) fL] and PDW (20 +/- 6.4)% in OBS group were significantly higher than those in N-OBS group [(8 +/- 3.2) fL, (15 +/- 2.1)%] (P < 0.05). Logistic regression showed that BT occlusion was not related to the tube diameter and PC value (P > 0.05). Abnormal increases of MPV and PDW increased the risk of ductal occlusion [(OR = 2.1, 95%CI: 1.47-2.49, P < 0.05), (OR = 2.4, 95%CI: 1.71-3.87, P < 0.05)]. Conclusion: Improved BT postoperative occlusion are closely related to MPV and PDW. Increased MPV and PDW can increase the risk of postoperative BT occlusion. (C) 2018 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81371443, 8140030]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7122056, 7142049, 7142137, 7152045]; Xinjiang Uygur Autonomous Region Natural Science Foundation [2014211A063]; Beijing Outstanding Talent Training Project [2014000021469G233]; Beijing Health Bureau High-level Talent Training Project [2014-3-043]; Beijing Municipal Administration of Hospitals Incubating Program [PX2016046]; Fund of Capital Medical University Clinical-Basic Cooperation Research [13JL26]
第一作者机构：[a]Cardiovascular Surgery II, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
通讯作者：
通讯机构：[a]Cardiovascular Surgery II, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China[*1]Cardiovascular Surgery II, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, No.56, Lishi Road, Xichen District, Beijing, 100045, China.
推荐引用方式(GB/T 7714)：
Zhu Yaobin,Zhang Yaping,Liu Yang,et al.Study on the correlation of modified Blalock Taussig duct occlusion and platelet parameters in congenital heart disease[J].ASIAN JOURNAL OF SURGERY.2019,42(5):599-603.doi:10.1016/j.asjsur.2018.08.012.
APA：
Zhu, Yaobin,Zhang, Yaping,Liu, Yang,Fan, Xing,Ding, Nan&Li, Zhiqiang.(2019).Study on the correlation of modified Blalock Taussig duct occlusion and platelet parameters in congenital heart disease.ASIAN JOURNAL OF SURGERY,42,(5)
MLA：
Zhu, Yaobin,et al."Study on the correlation of modified Blalock Taussig duct occlusion and platelet parameters in congenital heart disease".ASIAN JOURNAL OF SURGERY 42..5(2019):599-603
