Intermittent Theta-Burst Stimulation Reverses the After-Effects of Contralateral Virtual Lesion on the Suprahyoid Muscle Cortex: Evidence From Dynamic Functional Connectivity Analysis
机构：[1]Department of Radiology, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China,[2]The Second Affiliated Hospital, South China University of Technology, Guangzhou, China,[3]Department of Rehabilitation Medicine, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China,[4]Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China,[5]Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院
Contralateral intermittent theta burst stimulation (iTBS) can potentially improve swallowing disorders with unilateral lesion of the swallowing cortex. However, the after-effects of iTBS on brain excitability remain largely unknown. Here, we investigated the alterations of temporal dynamics of inter-regional connectivity induced by iTBS following continuous TBS (cTBS) in the contralateral suprahyoid muscle cortex. A total of 20 right-handed healthy subjects underwent cTBS over the left suprahyoid muscle motor cortex and then immediately afterward, iTBS was applied to the contralateral homologous area. All of the subjects underwent resting-state functional magnetic resonance imaging (Rs-fMRI) pre- and post-TBS implemented on a different day. We compared the static and dynamic functional connectivity (FC) between the post-TBS and the baseline. The whole-cortical time series and a sliding-window correlation approach were used to quantify the dynamic characteristics of FC. Compared with the baseline, for static FC measurement, increased FC was found in the precuneus (BA 19), left fusiform gyrus (BA 37), and right pre/post-central gyrus (BA 4/3), and decreased FC was observed in the posterior cingulate gyrus (PCC) (BA 29) and left inferior parietal lobule (BA 39). However, in the dynamic FC analysis, post-TBS showed reduced FC in the left angular and PCC in the early windows, and in the following windows, increased FC in multiple cortical areas including bilateral pre-and postcentral gyri and paracentral lobule and non-sensorimotor areas including the prefrontal, temporal and occipital gyrus, and brain stem. Our results indicate that iTBS reverses the aftereffects induced by cTBS on the contralateral suprahyoid muscle cortex. Dynamic FC analysis displayed a different pattern of alteration compared with the static FC approach in brain excitability induced by TBS. Our results provide novel evidence for us in understanding the topographical and temporal aftereffects linked to brain excitability induced by different TBS protocols and might be valuable information for their application in the rehabilitation of deglutition.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81371441, 81572230, 81871846]; Guangdong Provincial Science and Technology Program [2013B051000036, 2014B020212001]; Guangzhou Municipal Science and Technology Program [2016201604030036]; Science and Technology Planning Project of Guangzhou [201804010032]
第一作者机构：[1]Department of Radiology, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Radiology, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China,[2]The Second Affiliated Hospital, South China University of Technology, Guangzhou, China,[3]Department of Rehabilitation Medicine, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China,[5]Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Guoqin Zhang,Xiuhang Ruan,Yuting Li,et al.Intermittent Theta-Burst Stimulation Reverses the After-Effects of Contralateral Virtual Lesion on the Suprahyoid Muscle Cortex: Evidence From Dynamic Functional Connectivity Analysis[J].FRONTIERS IN NEUROSCIENCE.2019,13(APR):-.doi:10.3389/fnins.2019.00309.
APA：
Guoqin Zhang,Xiuhang Ruan,Yuting Li,E Li,Cuihua Gao...&Xinhua Wei.(2019).Intermittent Theta-Burst Stimulation Reverses the After-Effects of Contralateral Virtual Lesion on the Suprahyoid Muscle Cortex: Evidence From Dynamic Functional Connectivity Analysis.FRONTIERS IN NEUROSCIENCE,13,(APR)
MLA：
Guoqin Zhang,et al."Intermittent Theta-Burst Stimulation Reverses the After-Effects of Contralateral Virtual Lesion on the Suprahyoid Muscle Cortex: Evidence From Dynamic Functional Connectivity Analysis".FRONTIERS IN NEUROSCIENCE 13..APR(2019):-
