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Hepatitis B virus infected patients show increased risk of cerebral aneurysm rupture: A retrospective analysis

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收录情况： ◇ SCIE

作者：
Yang, Ziwen[a,b,c,d] * ; Wang, Jia[a,b,c,d] ; Zhang, Dong[a,b,c,d] ; Wang, Shuo[a,b,c,d] ; Wang, Rong[a,b,c,d] ; Zhao, Jizong[a,b,c,d,*1] ;
机构： [a]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China [b]China National Clinical Research Center for Neurological Diseases, Beijing, PR China [c]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, PR China [d]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, PR China
出处：
DOI： 10.1016/j.jocn.2019.01.023
ISSN：

关键词： Rupture Cerebral aneurysm Hepatitis B virus HBsAg Anti-HBc

摘要：
Background: The mechanism responsible for cerebral aneurysm (CA) formation and rupture remains unclear. Some studies showed vascular involvement could be observed in systemic vasculitis caused by Hepatitis B. Therefore, it is necessary to determine the possibility by which hepatitis B virus (HBV) infection might be associated with CA. Methods and Results: We retrospectively studied patient details and serological markers of HBV infection among 229 patients presenting with CA on admission to the Neurosurgery Department at Beijing Tiantan Hospital between March 2016 and February 2017. Clinical data, radiologic findings and clinical features of HBV infection were analyzed by SPSS. The results showed a significant association between HBsAg positive (p = 0.014), anti-HBc positive (p = 0.045) and CA rupture. Univariate analysis revealed patients that were HBsAg positive (OR: 4.828; 95% Cl: 1.363-17.099; p = 0.015) and anti-HBc positive (OR: 1.804; 95% Cl: 1.010-3.223; p = 0.046) were associated with CA rupture. Compared with other confounding risk factors for rupture in the statistical analysis, HBsAg positive status (OR: 4.085; 95% CI: 1.011-16.513; p = 0.048) remained positively associated with CA rupture. Conclusions: Observation showed that HBsAg positivity was associated with CA rupture. (C) 2019 Published by Elsevier Ltd.

基金：
Key Project of Beijing Municipal Science and Technology Commission [D161100003816004]; International Science and Technique Cooperation Program of China [2010DFB30850]; Training Plan of High-Level Technical Talents in the Beijing Health System [2015-3-041]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 神经科学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 神经科学
JCR分区：
出版当年[2017]版：
Q4 NEUROSCIENCES Q4 CLINICAL NEUROLOGY
最新[2023]版：
Q3 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [a]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China [b]China National Clinical Research Center for Neurological Diseases, Beijing, PR China [c]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, PR China [d]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, PR China
通讯作者：
通讯机构： [a]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China [b]China National Clinical Research Center for Neurological Diseases, Beijing, PR China [c]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, PR China [d]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, PR China [*1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Dongcheng District, Beijing 100050, PR China.
推荐引用方式(GB/T 7714)：
Yang Ziwen,Wang Jia,Zhang Dong,et al.Hepatitis B virus infected patients show increased risk of cerebral aneurysm rupture: A retrospective analysis[J].JOURNAL OF CLINICAL NEUROSCIENCE.2019,63:155-159.doi:10.1016/j.jocn.2019.01.023.
APA：
Yang, Ziwen,Wang, Jia,Zhang, Dong,Wang, Shuo,Wang, Rong&Zhao, Jizong.(2019).Hepatitis B virus infected patients show increased risk of cerebral aneurysm rupture: A retrospective analysis.JOURNAL OF CLINICAL NEUROSCIENCE,63,
MLA：
Yang, Ziwen,et al."Hepatitis B virus infected patients show increased risk of cerebral aneurysm rupture: A retrospective analysis".JOURNAL OF CLINICAL NEUROSCIENCE 63.(2019):155-159

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