机构：[1]Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050研究所北京市神经外科研究所首都医科大学附属天坛医院[2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院
Gliomas are the most common and lethal type of primary malignant central nervous system tumors, with an extremely poor prognosis. The latest progression in the technological development of sequencing/microarray and bioinformatics has provided insights into the glioma genome. These technologies have generated large amounts of easily accessible biological omics data, providing an unprecedented opportunity to study glioma formation. According to the 2016 WHO organization classification of brain tumors, gliomas are currently diagnosed with respect to morphological and molecular tumor alterations, especially for isocitrate dehydrogenase and 1p/19q codeletions. In the present study, the comprehensive molecular profiling and available omics data resources for malignant gliomas were reviewed for novel insights into the biology and classification of these tumors. These molecular profiling resources may be useful for improving the understanding of malignant gliomas, and to accelerate the clinical, experimental and epidemiological studies that may lead to improvements in the lives of patients with glioma.
基金：
National Key Research and Development Plan [2016YFC0902500]
语种：
外文
被引次数：
WOS：
PubmedID：
第一作者：
第一作者机构：[1]Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050
共同第一作者：
通讯作者：
通讯机构：[1]Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050[*1]Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, 6 Tiantan Xili, Dongcheng, Beijing 100050, P.R. China
推荐引用方式(GB/T 7714)：
Zhao Zheng,Zhang Kenan,Wang Zhiliang,et al.A comprehensive review of available omics data resources and molecular profiling for precision glioma studies[J].BIOMEDICAL REPORTS.2019,10(1):3-9.doi:10.3892/br.2018.1168.
APA：
Zhao, Zheng,Zhang, Kenan,Wang, Zhiliang,Wang, Kuanyu,Liu, Xing...&Chen, Jing.(2019).A comprehensive review of available omics data resources and molecular profiling for precision glioma studies.BIOMEDICAL REPORTS,10,(1)
MLA：
Zhao, Zheng,et al."A comprehensive review of available omics data resources and molecular profiling for precision glioma studies".BIOMEDICAL REPORTS 10..1(2019):3-9
