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Anterior insular cortex plays a critical role in interoceptive attention

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收录情况： ◇ SCIE ◇ 自然指数

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机构： [1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2]China National Clinical Research Center for Neurological Diseases, Beijing, China [3]Beijing Key Lab of Learning and Cognition, School of Psychology, Capital Normal University, Beijing, China [4]School of Psychological and Cognitive Sciences, Peking University, Beijing, China [5]Department of Psychology, Queens College, The City University of New York, New York, USA [6]Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA [7]Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, USA [8]Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, USA [9]Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China [10]Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, USA [11]Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA

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Accumulating evidence indicates that the anterior insular cortex (AIC) mediates interoceptive attention which refers to attention towards physiological signals arising from the body. However, the necessity of the AIC in this process has not been demonstrated. Using a novel task that directs attention toward breathing rhythm, we assessed the involvement of the AIC in interoceptive attention in healthy participants using functional magnetic resonance imaging and examined the necessity of the AIC in interoceptive attention in patients with AIC lesions. Results showed that interoceptive attention was associated with increased AIC activation, as well as enhanced coupling between the AIC and somatosensory areas along with reduced coupling between the AIC and visual sensory areas. In addition, AIC activation was predictive of individual differences in interoceptive accuracy. Importantly, AIC lesion patients showed disrupted interoceptive discrimination accuracy and sensitivity. These results provide compelling evidence that the AIC plays a critical role in interoceptive attention.

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出版当年[2018]版：

大类 | 1 区

生物

小类 | 1 区生物学

最新[2023]版：

大类 | 1 区

生物学

小类 | 1 区生物学

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出版当年[2017]版：

Q1 BIOLOGY

最新[2023]版：

Q1 BIOLOGY

影响因子： 6.4 最新[2023版] 7.2 最新五年平均 7.616 出版当年[2017版] 8.508 出版当年五年平均 7.725 出版前一年[2016版] 7.551 出版后一年[2018版]

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第一作者机构： [1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2]China National Clinical Research Center for Neurological Diseases, Beijing, China

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通讯作者：

通讯机构： [1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2]China National Clinical Research Center for Neurological Diseases, Beijing, China [4]School of Psychological and Cognitive Sciences, Peking University, Beijing, China [5]Department of Psychology, Queens College, The City University of New York, New York, USA [6]Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA [9]Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China [10]Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, USA [11]Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA [*1]Department of Psychology, Peking University, Beijing, 100080, China [*2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China [*3]Department of Psychology, Queens College, The City University of New York, Queens, NY 11367, USA

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