机构:[1]National Health Commission Key Laboratory of Systems Biology of Pathogens, Beijing, China[2]Institute of Pathogen Biology of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing[3]Capital Medical University Beijing Children’s Hospital, Beijing首都医科大学附属北京儿童医院
During July 2007-June 2015, we enrolled 4,225 hospitalized children with pneumonia in a study to determine the seasonality of respiratory syncytial virus (RSV) infection in Beijing, China. We defined season as the period during which >10% of total PCRs performed each week were RSV positive. We identified 8 distinctive RSV seasons. On average, the season onset occurred at week 41 (mid-October) and lasted 33 weeks, through week 20 of the next year (mid-May); 97% of all RSV-positive cases occurred during the season. RSV seasons occurred 3-5 weeks earlier and lasted weeks longer in RSV subgroup A-dominant years than in RSV subgroup B-dominant years. Our analysis indicates that monitoring such RSV subgroup shifts might provide better estimates for the onset of RSV transmission. PCR-based tests could be a flexible or complementary way of determining RSV seasonality in locations where RSV surveillance is less well-established, such as local hospitals throughout China.
基金:
National Major Science and Technology Project for Control and Prevention of Major Infectious Diseases in China [2017ZX10103004]; Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences [2016-I2M-1-014]; Peking Union Medical College Postdoctoral Fund; Foundation Merieux
第一作者机构:[1]National Health Commission Key Laboratory of Systems Biology of Pathogens, Beijing, China[2]Institute of Pathogen Biology of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
共同第一作者:
通讯作者:
通讯机构:[1]National Health Commission Key Laboratory of Systems Biology of Pathogens, Beijing, China[2]Institute of Pathogen Biology of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing[*1]Institute of Pathogen Biology of Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Dong Dan San Tiao, Dongcheng District, Beijing 100730, China