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Behaviors of Glioblastoma Cells in in Vitro Microenvironments

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收录情况： ◇ SCIE

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机构： [1]Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, 55 East Zhongguancun Road, Beijing, 100190, China. [2]School of Physical Sciences, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China. [3]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. [4]Beijing National Laboratory for Condensed Matter Physics and CAS Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China. [5]Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, 325001, China. [6]School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. [7]College of Physics, Chongqing University, Chongqing, 401331, China

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摘要：

Glioblastoma (GBM) is the most malignant and highly aggressive brain tumor. In this study, four types of typical GBM cell lines (LN229, SNB19, U87, U251) were cultured in a microfabricated 3-D model to study their in vitro behaviors. The 3-D in vitro model provides hollow micro-chamber arrays containing a natural collagen interface and thus allows the GBM cells to grow in the 3-D chambers. The GBM cells in this model showed specific properties on the aspects of cell morphology, proliferation, migration, and invasion, some of which were rarely observed before. Furthermore, how the cells invaded into the surrounding ECM and the corresponding specific invasion patterns were observed in details, implying that the four types of cells have different features during their development in cancer. This complex in vitro model, if applied to patient derived cells, possesses the potential of becoming a clinically relevant predictive model.

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出版当年[2018]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

最新[2023]版：

大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

JCR分区：

出版当年[2017]版：

Q1 MULTIDISCIPLINARY SCIENCES

最新[2023]版：

Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 3.8 最新[2023版] 4.3 最新五年平均 4.122 出版当年[2017版] 4.609 出版当年五年平均 4.259 出版前一年[2016版] 4.011 出版后一年[2018版]

第一作者：

第一作者机构： [1]Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, 55 East Zhongguancun Road, Beijing, 100190, China. [2]School of Physical Sciences, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China.

通讯作者：

通讯机构： [1]Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, 55 East Zhongguancun Road, Beijing, 100190, China. [2]School of Physical Sciences, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China. [3]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. [4]Beijing National Laboratory for Condensed Matter Physics and CAS Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China.

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