Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761((R))
机构：[1]Duke‐NUS Singapore, National Neuroscience Institute, Singapore, Singapore[2]Hasan Sadikin General Hospital, Bandung, Indonesia[3]School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia[4]Changi General Hospital, Singapore, Singapore[5]Singapore General Hospital, Singapore, Singapore[6]Department of Medicine, National University of Singapore, Singapore, Singapore[7]Department of Pharmacology, National University of Singapore, Singapore, Singapore[8]St Luke's Medical Center, Quezon City, Philippines[9]University of Santo Tomas, Metro Manila, Philippines[10]Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam[11]Hospital Sultan Ismail, Johor, Malaysia[12]Hospital Kuala Lumpur, Kuala Lumpur, Malaysia[13]Subang Jaya Medical Centre, Selangor, Malaysia[14]Ramathibodi Hospital, Bangkok, Thailand[15]Faculty of Pharmacy, Mahidol University, Bangkok, Thailand[16]Siriraj Hospital, Bangkok, Thailand[17]Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[18]Sahara Hospital, Lucknow, India[19]Alexian Hospital, Krefeld, Germany
Background The Ginkgo biloba special extract, EGb 761((R)) has been widely used in the treatment of neuropsychiatric disorders, including Alzheimer's disease (AD). Methods To guide clinical practice in the Asian region, the Asian Clinical Expert Group on Neurocognitive Disorders compiled evidence-based consensus recommendations regarding the use of EGb 761((R)) in neurocognitive disorders with/without cerebrovascular disease. Results Key randomized trials and robust meta-analyses have demonstrated significant improvement in cognitive function, neuropsychiatric symptoms, activities of daily living (ADL) and quality of life with EGb 761((R))versus placebo in patients with mild-to-moderate dementia. In those with mild cognitive impairment (MCI), EGb 761((R)) has also demonstrated significant symptomatic improvement versus placebo. World Federation of Societies of Biological Psychiatry guidelines list EGb 761((R)) with the same strength of evidence as acetylcholinesterase inhibitors and N-methyl-D-aspartate (NMDA) antagonists e.g. memantine (Grade 3 recommendation; Level B evidence). Only EGb 761((R)) had Level B evidence in improving cognition, behaviour, and ADL in both AD and vascular dementia patients. Safety analyses show EGb 761((R)) to have a positive risk-benefit profile. While concerns have been raised regarding a possible increased bleeding risk, several randomized trials and two meta-analyses have not supported this association. Conclusions The Expert Group foresee an important role for EGb 761((R)), used alone or as an add-on therapy, in the treatment of MCI and dementias, particularly when patients do not derive benefit from acetylcholinesterase inhibitors or NMDA antagonists. EGb 761((R)) should be used in alignment with local clinical practice guidelines.
基金：
Schwabe Pharma Asia Pacific Pte Ltd,
together with Dr Willmar Schwabe GmbH
& Co. KG, provided funding for the writing
of this manuscript, and sponsorship for the
Expert Group advisory board meeting upon
which this consensus document was based.
第一作者机构：[1]Duke‐NUS Singapore, National Neuroscience Institute, Singapore, Singapore[*1]National Neuroscience Institute, Singapore, Singapore.
通讯作者：
通讯机构：[1]Duke‐NUS Singapore, National Neuroscience Institute, Singapore, Singapore[*1]National Neuroscience Institute, Singapore, Singapore.
推荐引用方式(GB/T 7714)：
Kandiah Nagaendran,Ong Paulus Anam,Yuda Turana,et al.Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761((R))[J].CNS NEUROSCIENCE & THERAPEUTICS.2019,25(2):288-298.doi:10.1111/cns.13095.
APA：
Kandiah, Nagaendran,Ong, Paulus Anam,Yuda, Turana,Ng, Li-Ling,Mamun, Kaysar...&Ihl, Ralf.(2019).Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761((R)).CNS NEUROSCIENCE & THERAPEUTICS,25,(2)
MLA：
Kandiah, Nagaendran,et al."Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761((R))".CNS NEUROSCIENCE & THERAPEUTICS 25..2(2019):288-298
