Abnormal Interactions of the Salience Network, Central Executive Network, and Default-Mode Network in Patients With Different Cognitive Impairment Loads Caused by Leukoaraiosis
机构：[1]Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,重点科室医技科室放射科放射科首都医科大学附属天坛医院[2]Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,首都医科大学附属天坛医院[3]Center of Stroke, National Clinical Research Center for Neurological Diseases, Beijing, China,[4]Beijing Institute for Brain Disorders, Beijing, China,[5]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China,[6]Beijing Key Laboratory of Central Nervous System Injury, Beijing, China,[7]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[8]Department of Neurology, Beijing Pinggu Hospital, Beijing, China,[9]Department of Neurology, General Hospital of The Yang Tze River Shipping, Wuhan Brain Hospital, Wuhan, China,[10]Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China医技科室核医学科首都医科大学附属天坛医院
Leukoaraiosis (LA) is associated with cognitive impairment in the older people which can be demonstrated in functional connectivity (FC) based on resting-state functional magnetic resonance imaging (rs-fMRI). This study is to explore the FC changes in LA patients with different cognitive status by three network models. Fifty-three patients with LA were divided into three groups: the normal cognition (LA-NC; n = 14, six males), mild cognitive impairment (LA-MCI; n = 27, 13 males), and vascular dementia (LA-VD; n = 12, six males), according to the Mini Mental State Exam (MMSE) and Clinical Dementia Rating (CDR). The three groups and 30 matched healthy controls (HCs; 11 males) underwent rs-fMRI. The data of rs-fMRI were analyzed by independent components analysis (ICA) and region of interest (ROI) analysis by the REST toolbox. Then the FC was respectively analyzed by the default-mode network (DMN), salience networks (SNs) and the central executive network (CEN) with their results compared among the different groups. For inter-brain network analysis, there were negative FC between the SN and DMN in LA groups, and the FC decreased when compared with HC group. While there were enhanced inter-brain network FC between the SN and CEN as well as within the SN. The FC in patients with LA can be detected by different network models of rs-fMRI. The multi-model analysis is helpful for the further understanding of the cognitive changes in those patients.
基金：
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201836]; National Key Technology Research and Development Program of ChinaNational Key Technology R&D Program [2018YFC2002300, 2018YFC2002302, 2015BAI12B02]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [NSFC: 81371201, 81772005]; National Key Technology Research and Development Program of the Ministry of Science and Technology of The People's Republic of China [2015BAI12B04]; National Key Research and Development Program of China [2018YFC0115604]
第一作者机构：[1]Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,
通讯作者：
通讯机构：[2]Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,[3]Center of Stroke, National Clinical Research Center for Neurological Diseases, Beijing, China,[4]Beijing Institute for Brain Disorders, Beijing, China,[5]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China,[6]Beijing Key Laboratory of Central Nervous System Injury, Beijing, China,[7]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,
推荐引用方式(GB/T 7714)：
Hongyan Chen,Yuexiu Li,Qi Liu,et al.Abnormal Interactions of the Salience Network, Central Executive Network, and Default-Mode Network in Patients With Different Cognitive Impairment Loads Caused by Leukoaraiosis[J].FRONTIERS IN NEURAL CIRCUITS.2019,13:-.doi:10.3389/fncir.2019.00042.
APA：
Hongyan Chen,Yuexiu Li,Qi Liu,Qingli Shi,Jingfang Wang...&Yu Mei Zhang.(2019).Abnormal Interactions of the Salience Network, Central Executive Network, and Default-Mode Network in Patients With Different Cognitive Impairment Loads Caused by Leukoaraiosis.FRONTIERS IN NEURAL CIRCUITS,13,
MLA：
Hongyan Chen,et al."Abnormal Interactions of the Salience Network, Central Executive Network, and Default-Mode Network in Patients With Different Cognitive Impairment Loads Caused by Leukoaraiosis".FRONTIERS IN NEURAL CIRCUITS 13.(2019):-
