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Disease severity and clinical outcomes of community-acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicentre prospective registry study from the CAP-China Network

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收录情况： ◇ SCIE

作者：
Fei Zhou[1,2,3] * ; Yimin Wang[1,2,3] * ; Yingmei Liu[1,2,3] * ; Xuedong Liu[4] * ; Li Gu[5] * ; Xiaoju Zhang[6] * ; Zenghui Pu[7] * ; Guoru Yang[8] * ; Bo Liu[9] * ; Qingrong Nie[10] ; Bing Xue[11] ; Jing Feng[12] ; Qiang Guo[13] ; Jianhua Liu[14] ; Hong Fan[15] ; Jin Chen[16] ; Yongxiang Zhang[17] ; Zhenyang Xu[18] ; Min Pang[19] ; Yu Chen[20] ; Xiuhong Nie[21] ; Zhigang Cai[22] ; Jinfu Xu[23] ; Kun Peng[24] ; Xiangxin Li[25] ; Pingchao Xiang[26] ; Zuoqing Zhang[27] ; Shujuan Jiang[28] ; Xin Su[29] ; Jie Zhang[30] ; Yanming Li[31] ; Xiuhong Jin[32] ; Rongmeng Jiang[33] ; Jianping Dong[34] ; Yuanlin Song[35] ; Hong Zhou[36] ; Chen Wang[1,2,3] ; Bin Cao[1,2,3,*1] ;
机构： [1]Department of Pulmonary and Critical Care Medicine, Center for Respiratory Diseases, National Clinical Research Center of Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China [2]Clinical Center for Pulmonary Infections, Capital Medical University. [3]Tsinghua University-Peking University Joint Center for Life Sciences. [4]Department of Respiratory Medicine, Qingdao Municipal Hospital Group, Jiaozhou Road, Qingdao City, Shandong Province, China. [5]Department of Infectious Diseases, Beijing Chao-Yang Hospital, Capital Medical University, No 8, Gongti Road, Chaoyang District, Beijing, China. [6]Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou, China. [7]Department of Infectious diseases, YanTai Yu Huang-Ding Hospital, No. 20, Yu Huangding east Road, Yantai, China. [8]Department of Pulmonary and Critical Care Medicine, Weifang No. 2 People's Hospital, Yuanxiao Street, Weifang City, Shandong Province, China. [9]Department of Respiratory and Critical Care Medicine, Linzi District People’s Hospital, Shandong, China. [10]Department of Respiratory and Critical Care Medicine, Liangxiang Hospital, No. 45, Gongchen Road, Fangshan District, Beijing, China. [11]Department of Respiratory Medicine, Chuiyangliu Hospital Affiliated to Tshinghua University, No. 2, Chui Y angliu south Road, Beijing, China. [12]Department of Respiratory Medicine, Tianjin Medical University General Hospital, Tianjin, China. [13]Department of Respiratory, Emergency and Critical Care Medicine, First Affiliated Hospital of Soochow University, China. [14]Department of Respiratory, Beijing Huairou Hospital of University of Chinese Academy of Science, China. [15]Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichan University, China. [16]Department of Respiratory, Fuxing Hospital, Capital Medical University, China. [17]Department of Pulmonary and Critical Care Medicine, Daxing Hospital Affiliated to Capital Medical University, China. [18]Department of Pulmonary and Critical Care Medicine, Beijing Luhe Hospital, Capital Medical University, China. [19]Department of Respiratory, First Hospital of Shanxi Medical University, China. [20]Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, China. [21]Department of Respiratory, Xuanwu Hospital Capital Medical University, China. [22]Department of Respiratory, The Second Hospital of Hebei Medical University, China. [23]Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, China. [24]Department of Respiratory, Beijing No.6 Hospital, China [25]Department of Pulmonary and Critical Care Medicine, Beijing Changping Hospital, China. [26]Department of Pulmonary and Critical Care Medicine, Peking University Shougang Hospital, China. [27]Department of Respiratory, Beijing Shijingshan Hospital, China. [28]Department of Pulmonary and Critical Care Medicine, Shandong Province Hospital, China. [29]Department of Respiratory, Nanjing General Hospital of Nanjing Military Command, PLA, China. [30]Department of Respiratory, Beijing Tiantan Hospital, Capital Medical University, China. [31]Department of Pulmonary and Critical Care Medicine, Beijing Hospital, China. [32]Department of Respiratory, Beijing Pinggu Hospital, China. [33]The National Clinical Key Department of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, China [34]Department of Infectious diseases, Beijing Haidian hospital, Haidian section of Peking University Third Hospital, China. [35]Department of Respiratory, Zhongshan Hospital, Fudan University, China. [36]Department of Respiratory, Beijing electric power Hospital, China
出处：
DOI： 10.1183/13993003.02406-2018
ISSN：

摘要：
Although broad knowledge of influenza viral pneumonia has been established, the significance of non-influenza respiratory viruses in community-acquired pneumonia (CAP) and their impact on clinical outcomes remains unclear, especially in the non-immunocompromised adult population. Hospitalised immunocompetent patients with CAP were prospectively recruited from 34 hospitals in mainland China. Respiratory viruses were detected by molecular methods. Comparisons were conducted between influenza and non-influenza viral infection groups. In total, 915 out of 2336 adult patients with viral infection were enrolled in the analysis, with influenza virus (28.4%) the most frequently detected virus, followed by respiratory syncytial virus (3.6%), adenovirus (3.3%), human coronavirus (3.0%), parainfluenza virus (2.2%), human rhinovirus (1.8%) and human metapneumovirus (1.5%). Non-influenza viral infections accounted for 27.4% of viral pneumonia. Consolidation was more frequently observed in patients with adenovirus infection. The occurrence of complications such as sepsis (40.1% versus 39.6%; p=0.890) and hypoxaemia (40.1% versus 37.2%; p=0.449) during hospitalisation in the influenza viral infection group did not differ from that of the non-influenza viral infection group. Compared with influenza virus infection, the multivariable adjusted odds ratios of CURB-65 (confusion, urea > 7 mmol.L-1, respiratory rate >= 30 breaths.min(-1), blood pressure < 90 mmHg (systolic) or <= 60 mmHg (diastolic), age >= 65 years) >= 3, arterial oxygen tension/inspiratory oxygen fraction < 200 mmHg, and occurrence of sepsis and hypoxaemia for non-influenza respiratory virus infection were 0.87 (95% CI 0.26-2.84), 0.72 (95% CI 0.26-1.98), 1.00 (95% CI 0.63-1.58) and 1.05 (95% CI 0.66-1.65), respectively. The hazard ratio of 90-day mortality was 0.51 (95% CI 0.13-1.91). The high incidence of complications in non-influenza viral pneumonia and similar impact of non-influenza respiratory viruses relative to influenza virus on disease severity and outcomes suggest more attention should be given to CAP caused by non-influenza respiratory viruses.

基金：
This study was supported by grants from the National Science Fund for Distinguished Young Scholars (grant number 81425001/H0104), the Innovation Fund for Medical Sciences from the Chinese Academy of Medical Sciences (2018-I2M-1-003), the National Key Technology Support Program from the Ministry of Science and Technology (2015BAI12B11) and from the Beijing Science and Technology Project (D151100002115004).
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 1 区 医学
小类 | 1 区 呼吸系统
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 呼吸系统
JCR分区：
出版当年[2017]版：
Q1 RESPIRATORY SYSTEM
最新[2023]版：
Q1 RESPIRATORY SYSTEM

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]Department of Pulmonary and Critical Care Medicine, Center for Respiratory Diseases, National Clinical Research Center of Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China [2]Clinical Center for Pulmonary Infections, Capital Medical University. [3]Tsinghua University-Peking University Joint Center for Life Sciences.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Pulmonary and Critical Care Medicine, Center for Respiratory Diseases, National Clinical Research Center of Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China [2]Clinical Center for Pulmonary Infections, Capital Medical University. [3]Tsinghua University-Peking University Joint Center for Life Sciences. [*1]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, National Clinical Research Center of Respiratory Diseases, Clinical Center for Pulmonary Infections, Capital Medical University, Tsinghua University-Peking University Joint Center for Life Sciences
推荐引用方式(GB/T 7714)：
Fei Zhou,Yimin Wang,Yingmei Liu,et al.Disease severity and clinical outcomes of community-acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicentre prospective registry study from the CAP-China Network[J].EUROPEAN RESPIRATORY JOURNAL.2019,54(2):-.doi:10.1183/13993003.02406-2018.
APA：
Fei Zhou,Yimin Wang,Yingmei Liu,Xuedong Liu,Li Gu...&Bin Cao.(2019).Disease severity and clinical outcomes of community-acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicentre prospective registry study from the CAP-China Network.EUROPEAN RESPIRATORY JOURNAL,54,(2)
MLA：
Fei Zhou,et al."Disease severity and clinical outcomes of community-acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicentre prospective registry study from the CAP-China Network".EUROPEAN RESPIRATORY JOURNAL 54..2(2019):-

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