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Sirtuin 3 promotes microglia migration by upregulating CX3CR1

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收录情况： ◇ SCIE

作者：

机构： [a]Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China [b]Barrow Neurological Institute, St. Joseph Hospital and Medical Center, Dignity Health Organization, Phoenix, AZ, USA [c]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China [d]China National Clinical Research Center for Neurological Diseases, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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关键词： Ischemia SIRT3 microglia migration CX3CR1

摘要：

We studied the role of Sirtuin 3 (SIRT3) in microglial cell migration in ischemic stroke. We used a middle cerebral artery occlusion (MCAO) model of focal ischemia. We then applied lentivirus-packaged SIRT3 overexpression and knock down in microglial N9 cells to investigate the underlying mechanism driving microglial cell migration. More microglial cells appeared in the ischemic lesion side after MCAO. The levels of SIRT3 were increased in macrophages, the main source of microglia, after ischemia. CX3CR1 levels were increased with SIRT3 overexpression. SIRT3 promoted microglial N9 cells migration by upregulating CX3CR1 in both normal and glucose deprived culture media. These effects were G protein-dependent. Our study for the first time shows that SIRT3 promotes microglia migration by upregulating CX3CR1.

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出版当年[2018]版：

大类 | 2 区生物

小类 | 3 区细胞生物学

最新[2023]版：

大类 | 3 区生物学

小类 | 4 区细胞生物学

JCR分区：

出版当年[2017]版：

Q2 CELL BIOLOGY

最新[2023]版：

Q3 CELL BIOLOGY

影响因子： 3.3 最新[2023版] 3.3 最新五年平均 3.566 出版当年[2017版] 4.352 出版当年五年平均 3.872 出版前一年[2016版] 3.296 出版后一年[2018版]

第一作者：

第一作者机构： [a]Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China [b]Barrow Neurological Institute, St. Joseph Hospital and Medical Center, Dignity Health Organization, Phoenix, AZ, USA

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通讯作者：

通讯机构： [a]Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China [b]Barrow Neurological Institute, St. Joseph Hospital and Medical Center, Dignity Health Organization, Phoenix, AZ, USA [c]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China [d]China National Clinical Research Center for Neurological Diseases, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [*1]Department of Neurology, The Second Hospital of Hebei Medical University, No.215 Hepingxilu, Xinhua District, Shijiazhuang, Hebei 050000, China [*2]Barrow Neurological Institute, St. Joseph Hospital and Medical Center, Dignity Health Organization, 240 W. Thomas Road, Phoenix, AZ 85013, USA

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