机构：[1]Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, Genetics and Birth Defects Control Center, National Center for Children’s Health, MOE Key Laboratory of Major Diseases in Children, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China,科研平台职能科室出生缺陷遗传学研究室临床流行病与循证医学中心儿科研究所首都医科大学附属北京儿童医院[2]Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
Atherosclerosis is characterized by the accumulation of lipid-rich plaques in the arterial wall. Its pathogenesis is very complicated and has not yet been fully elucidated. It is known that dyslipidemia is a major factor in atherosclerosis. Several different Hermansky-Pudlak syndrome (HPS) mutant mice have been shown either anti-atherosclerotic or atherogenic phenotypes, which may be mainly attributed to corresponding lipid perturbation. To explore the effects of different HPS proteins on lipid metabolism and plasma lipid composition, we analyzed the plasma lipid profiles of three HPS mutant mice, pa (Hps9(-/-)), ru (Hps6(-/-)), ep (Hps1(-/-)), and wild-type (WT) mice. In pa and ru mice, some pro-atherosclerotic lipids, e.g. ceramide (Cer) and diacylglycerol (DAG), were down-regulated whereas triacylglycerol (TAG) containing docosahexaenoic acid (DHA) (22:6) fatty acyl was up-regulated when compared with WT mice. Several pro-atherosclerotic lipids including phosphatidic acid (PA), lysophosphatidylserine (LPS), sphingomyelin (SM), and cholesterol (Cho) were up-regulated in ep mice compared with WT mice. The lipid droplets in hepatocytes showed corresponding changes in these mutants. Our data suggest that the pa mutant resembles the ru mutant in its anti-atherosclerotic effects, but the ep mutant has an atherogenic effect. Our findings may provide clues to explain why different HPS mutant mice exhibit distinct anti-atherosclerotic or atherogenic effects after being exposed to high-cholesterol diets.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31830054, 91539204, 31671226]; Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2016YFC1000306]
第一作者机构：[1]Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, Genetics and Birth Defects Control Center, National Center for Children’s Health, MOE Key Laboratory of Major Diseases in Children, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China,
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, Genetics and Birth Defects Control Center, National Center for Children’s Health, MOE Key Laboratory of Major Diseases in Children, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China,[2]Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
推荐引用方式(GB/T 7714)：
Jing Ma,RaoxuWang,Sin Man Lam,et al.Plasma lipidomic profiling in murine mutants of Hermansky-Pudlak syndrome reveals differential changes in pro- and anti-atherosclerotic lipids[J].BIOSCIENCE REPORTS.2019,39(2):-.doi:10.1042/BSR20182339.
APA：
Jing Ma,RaoxuWang,Sin Man Lam,Chang Zhang,Guanghou Shui&Wei Li.(2019).Plasma lipidomic profiling in murine mutants of Hermansky-Pudlak syndrome reveals differential changes in pro- and anti-atherosclerotic lipids.BIOSCIENCE REPORTS,39,(2)
MLA：
Jing Ma,et al."Plasma lipidomic profiling in murine mutants of Hermansky-Pudlak syndrome reveals differential changes in pro- and anti-atherosclerotic lipids".BIOSCIENCE REPORTS 39..2(2019):-
