详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Localised grey matter atrophy in multiple sclerosis is network-based: a coordinate-based meta-analysis

文献详情

资源类型：

收录情况： ◇ SCIE

作者：

机构： [a]Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA [b]Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA [c]Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China [d]Division of Neuroradiology, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA [e]Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA [f]Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA [g]Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA [h]Harvard Medical School, Boston, MA, USA [i]Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA [j]South Texas Veterans Health Care System, San Antonio, TX, USA

出处：

DOI：

ISSN：

摘要：

AIM: To test the network degeneration hypothesis in multiple sclerosis (MS) with a two-stage coordinate-based meta-analysis by: (1) characterising regional selectivity of grey matter (GM) atrophy and (2) testing for functional connectivity involving these regions. MATERIALS AND METHODS: Meta-analytic sources included 33 journal articles (1,666 MS patients and 1,269 healthy controls) with coordinate-based results from voxel-based morphometry analysis demonstrating GM atrophy. Mass univariate and multivariate coordinate-based meta-analyses were performed to identify a convergent pattern of GM atrophy and determine inter-regional co-activation (as a surrogate of functional connectivity), with anatomical likelihood estimation and functional meta-analytic connectivity modelling, respectively. RESULTS: Localised GM atrophy was demonstrated in the thalamus, putamen, caudate, sensorimotor cortex, insula, superior temporal gyrus, and cingulate gyrus. This convergent pattern of atrophy displayed significant inter-regional functional co-activations. CONCLUSION: In MS, GM atrophy was regionally selective, and these regions were functionally connected. The meta-analytic model-based results of this study are intended to guide future development of quantitative neuroimaging markers for diagnosis, evaluating disease progression, and monitoring treatment response. Published by Elsevier Ltd on behalf of The Royal College of Radiologists.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2018]版：

大类 | 4 区医学

小类 | 3 区核医学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区核医学

JCR分区：

出版当年[2017]版：

Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

最新[2023]版：

Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 2.1 最新[2023版] 2.2 最新五年平均 2.282 出版当年[2017版] 2.057 出版当年五年平均 2.141 出版前一年[2016版] 2.082 出版后一年[2018版]

第一作者：

第一作者机构： [a]Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA [b]Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA [*1]Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl DriveeMC7800, San Antonio, TX, 78229, USA

通讯作者：

通讯机构： [a]Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA [b]Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA [e]Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA [*1]Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl DriveeMC7800, San Antonio, TX, 78229, USA [*2]Research Imaging Institute, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl DriveeMC 6240, San Antonio, TX 78229, USA.

推荐引用方式(GB/T 7714)：

APA：

MLA：