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Glucocorticoids pharmacology and their application in the treatment of childhood-onset systemic lupus erythematosus

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收录情况： ◇ SCIE

作者：

机构： [a]Department of Rheumatology, Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical University, No. 56 Nanlishi Road, Xicheng District, Beijing 100045, China [b]Division of Rheumatology, Cincinnati Children's Hospital Medical Center, MLC 4010, 3333 Burnet Avenue, Cincinnati, OH 45229, USA [c]Division of Immunology, Allergy, and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, USA [d]Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA

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关键词： Childhood-onset systemic lupus erythematosus Glucocorticoids Pharmacodynamics Pharmacokinetics

摘要：

Glucocorticoids are potent anti-inflammatory and immunosuppressant medications and remain the mainstay of systemic lupus erythematosus (SLE) therapy. The potency of a specific glucocorticoid, i.e., the dose of glucocorticoid that is required to produce a specific effect, is dependent on its pharmacokinetic (PK) and pharmacodynamic (PD) properties. In this review, we summarize the PK/PD properties of commonly used glucocorticoids in an attempt to better delineate their role in the management of children with childhood-onset SLE (cSLE). We also address glucocorticoid side effects as these play a major role when deciding on the dose, frequency, and duration of use. A better understanding of the pharmacology of glucocorticoids appears useful to achieve improved outcomes in the management of cSLE. © 2019 Elsevier Inc.

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中科院(CAS)分区：

出版当年[2018]版中科院分区表Review为是的期刊

：

大类 | 2 区医学

小类 | 2 区风湿病学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区风湿病学

JCR分区：

出版当年[2017]版：

Q1 RHEUMATOLOGY

最新[2023]版：

Q1 RHEUMATOLOGY

影响因子： 4.6 最新[2023版] 4.9 最新五年平均 4.356 出版当年[2017版] 4.919 出版当年五年平均 4.498 出版前一年[2016版] 5.072 出版后一年[2018版]

第一作者：

第一作者机构： [a]Department of Rheumatology, Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical University, No. 56 Nanlishi Road, Xicheng District, Beijing 100045, China [b]Division of Rheumatology, Cincinnati Children's Hospital Medical Center, MLC 4010, 3333 Burnet Avenue, Cincinnati, OH 45229, USA

通讯作者：

通讯机构： [a]Department of Rheumatology, Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical University, No. 56 Nanlishi Road, Xicheng District, Beijing 100045, China [b]Division of Rheumatology, Cincinnati Children's Hospital Medical Center, MLC 4010, 3333 Burnet Avenue, Cincinnati, OH 45229, USA

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Glucocorticoids pharmacology and their application in the treatment of childhood-onset systemic lupus erythematosus

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