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Intestinal Microbiota in Early Life and Its Implications on Childhood Health

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收录情况: ◇ 统计源期刊 ◇ CSCD-C

机构: [1]Affiliated Bayi Children’s Hospital, The Seventh Medical Center of PLA General Hospital, Beijing 100700, China [2]The First Clinical Academy of Dalian Medical University, Dalian 116011, China [3]College of the Environment, Northeast Normal University, Changchun 130117, China [4]National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing 100700, China [5]Beijing Key Laboratory of Pediatric Organ Failure, Beijing 100700, China
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关键词: Diseases Early life Gut–brain axis Immunity Intestinal microbiota Microbiota manipulation

摘要:
Trillions of microbes reside in the human body and participate in multiple physiological and pathophysiological processes that affect host health throughout the life cycle. The microbiome is hallmarked by distinctive compositional and functional features across different life periods. Accumulating evidence has shown that microbes residing in the human body may play fundamental roles in infant development and the maturation of the immune system. Gut microbes are thought to be essential for the facilitation of infantile and childhood development and immunity by assisting in breaking down food substances to liberate nutrients, protecting against pathogens, stimulating or modulating the immune system, and exerting control over the hypothalamic–pituitary–adrenal axis. This review aims to summarize the current understanding of the colonization and development of the gut microbiota in early life, highlighting the recent findings regarding the role of intestinal microbes in pediatric diseases. Furthermore, we also discuss the microbiota-mediated therapeutics that can reconfigure bacterial communities to treat dysbiosis. © 2019 The Authors

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出版当年[2018]版:
大类 | 1 区 生物
小类 | 2 区 遗传学
最新[2023]版:
大类 | 2 区 生物学
小类 | 3 区 遗传学
第一作者:
第一作者机构: [1]Affiliated Bayi Children’s Hospital, The Seventh Medical Center of PLA General Hospital, Beijing 100700, China [4]National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing 100700, China [5]Beijing Key Laboratory of Pediatric Organ Failure, Beijing 100700, China
通讯作者:
通讯机构: [1]Affiliated Bayi Children’s Hospital, The Seventh Medical Center of PLA General Hospital, Beijing 100700, China [4]National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing 100700, China [5]Beijing Key Laboratory of Pediatric Organ Failure, Beijing 100700, China
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