个人科研网厅 | | 帮助
首都医科大学宣武医院知识库
高级检索
当前位置： 首页 > 详情页

Glioma-associated human endothelial cell-derived extracellular vesicles specifically promote the tumourigenicity of glioma stem cells via CD9

| 认领 | 导出 | |

文献详情

资源类型：

收录情况： ◇ SCIE

作者：
Dengke Li[1] * ; Yuan Tian[1] ; Yan Hu[1] ; Yingjiao Qi[1] ; Ningyu Tian[1] ; Shanshan Li[1] ; Peishan Hu[1] ; Fan Wu[2] ; Qunfang Wei[1] ; Zhizhong Wei[1,3] ; Shanshan Wang[1] ; Bin Yin[1] ; Tao Jiang[2,4] ; Jiangang Yuan[1] ; Boqin Qiang[1] ; Wei Han[1] ; Xiaozhong Peng[1,2] ;
机构： [1]State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China [2]Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China [3]Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, China [4]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
出处：
DOI： 10.1038/s41388-019-0903-6
ISSN：

摘要：
The perivascular niche in glioma is critical for the maintenance of glioma stem cells (GSCs), and tumour-endothelial cell (EC) communication impacts tumourigenesis in ways that are incompletely understood. Here, we show that glioma-associated human endothelial cells (GhECs), a main component of the perivascular niche, release extracellular vesicles (EVs) that increase GSC proliferation and tumour-sphere formation. GSCs treated with GhEC-EVs create a significantly greater tumour burden than do untreated GSCs in orthotopic xenografts. Mechanistic, analysis of EVs content identified CD9 as a mediator of the effects on GSCs. CD9 can activate the BMX/STAT3 signalling pathway in GSCs. Our results illuminate the tumour-supporting role of ECs by identifying that EC-derived EVs transfer of CD9 during intercellular communication, thereby enhancing the aggressiveness of glioblastoma by specifically maintaining GSCs. © 2019, The Author(s), under exclusive licence to Springer Nature Limited.

基金：
Funding The National Key Research and Development Program of China (2016YFC0902500, 2016YFC0902502 and 2016YFA0100702), and National Sciences Foundation of China (31671316, 31670789), CAMS Innovation Fund for Medical Sciences (CIFMS, 2016-I2M-1–001, 2016-I2M-2–001, 2016-I2M-1–004, 2017-I2M-2–004, 2017-I2M-3–010 and 2017-I2M-1–004).
语种：
外文
被引次数：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 1 区 医学
小类 | 1 区 遗传学 2 区 生化与分子生物学 2 区 细胞生物学 2 区 肿瘤学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 生化与分子生物学 1 区 遗传学 2 区 细胞生物学 2 区 肿瘤学
JCR分区：
出版当年[2017]版：
Q1 GENETICS & HEREDITY Q1 ONCOLOGY Q1 CELL BIOLOGY Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY Q1 GENETICS & HEREDITY Q1 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China
通讯作者：
通讯机构： [1]State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China [2]Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Dengke Li,Yuan Tian,Yan Hu,et al.Glioma-associated human endothelial cell-derived extracellular vesicles specifically promote the tumourigenicity of glioma stem cells via CD9[J].Oncogene.2019,doi:10.1038/s41388-019-0903-6.
APA：
Dengke Li,Yuan Tian,Yan Hu,Yingjiao Qi,Ningyu Tian...&Xiaozhong Peng.(2019).Glioma-associated human endothelial cell-derived extracellular vesicles specifically promote the tumourigenicity of glioma stem cells via CD9.Oncogene,,
MLA：
Dengke Li,et al."Glioma-associated human endothelial cell-derived extracellular vesicles specifically promote the tumourigenicity of glioma stem cells via CD9".Oncogene .(2019)

资源点击量：16409 今日访问量：0 总访问量：869 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持：重庆聚合科技有限公司 地址：北京市西城区长椿街45号宣武医院