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Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway

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机构： [a]Shanxi Medical University, Taiyuan, China [b]China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [c]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China [d]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China [e]Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China [f]Center for Neurological Diseases, The Third People’s Hospital of Datong, Shanxi, China

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关键词： axonal remodeling colivelin ischemic stroke JAK/STAT3 neuronal death

摘要：

Colivelin is a neuroprotective humanin family peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. We seek to investigate whether this effect of Colivelin also govern ischemic brain injury, and potential mechanism underlying the Colivelin-mediated action on ischemic neurons. We adopted 60 min induction of transient focal cerebral ischemia and reperfusion in mice. We found that relative to mice receiving vehicle, Colivelin administration decreased the neurological deficits and infarct lesion induced by brain ischemia. Colivelin inhibited axonal damage and neuronal death in brain tissue, which was associated with elevated anti-apoptotic gene expression in ischemic neurons as well as increased axonal growth up until two-weeks post-stroke. Moreover, Colivelin activated STAT3 signaling, which may partially contribute to its beneficial effect against neuronal death and axon growth. In conclusion, Colivelin induce anti-apoptotic genes up-regulation, and activate JAK/STAT3 signaling after ischemic stroke, which may contribute to its effects of rescuing ischemic neuronal death and axonal remodeling. This study may justify further works to examine Colivelin as a single or adjunct therapy in ischemic stroke. © 2019 Elsevier Ltd

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出版当年[2018]版：

大类 | 3 区医学

小类 | 3 区神经科学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区神经科学

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出版当年[2017]版：

Q2 NEUROSCIENCES

最新[2023]版：

Q2 NEUROSCIENCES

影响因子： 2.9 最新[2023版] 3 最新五年平均 3.382 出版当年[2017版] 3.362 出版当年五年平均 3.277 出版前一年[2016版] 3.244 出版后一年[2018版]

第一作者：

第一作者机构： [a]Shanxi Medical University, Taiyuan, China [e]Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China

通讯作者：

通讯机构： [a]Shanxi Medical University, Taiyuan, China [b]China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [c]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China [d]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China [e]Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China [*1]Shanxi Medical University, Taiyuan, China.

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Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway

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