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The Association of Circulating T Follicular Helper Cells and Regulatory Cells with Acute Myeloid Leukemia Patients

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收录情况： ◇ SCIE

作者：

机构： [a]Department of Hematology/Oncology, First Hospital of Tsinghua University, Beijing, China [b]Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, Beijing, China [c]Department of Hematopoietic Stem Cell Transplantation, the 307 Hospital of Chinese PLA, Beijing, China [d]Department of Hematology/Oncology, Beijing Tsinghua Changgung Hospital, Beijing, China [e]Department of Hematology, Beijing No. 6 Hospital, Beijing, China

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摘要：

Objective: This study aims to investigate the association of circulating T follicular helper (cTfh) cells and T follicular regulatory (cTfr) cells with acute myeloid leukemia (AML) patients. Methods: A total of 22 newly diagnosed, untreated AML patients as well as 26 healthy controls were enrolled. Percentages of cTfh and cTfr cells were detected using flow cytometry. Results: Compared to healthy controls, a significantly higher percentage of cTfr cells was observed in AML patients (4.10 ± 11.18 vs. 0.63 ± 0.38%) (p < 0.05). In addition, a significantly lower cTfh/cTfr ratio was found in the AML patients' group when compared to the control group (9.04 ± 9.19 vs. 11.66 ± 5.68) (p < 0.05). A lower level of plasma IL-2 and TGF-β1 was found in AML patients. Based on the complete remission (CR) response after one cycle of inductive chemotherapy, patients were divided into two groups at sample collection: AML with and without CR. Significantly lower percentages of cTfr cells and a higher cTfh/cTfr ratio were found in the group of AML patients with CR than in the AML patients without CR. Conclusion: There was a significantly higher percentage of cTfr cells in AML patients. cTfr cells may have a potential association with the pathogenesis of AML patients. © 2019 S. Karger AG, Basel.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区血液学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区血液学

JCR分区：

出版当年[2017]版：

Q4 HEMATOLOGY

最新[2023]版：

Q3 HEMATOLOGY

影响因子： 1.7 最新[2023版] 2.1 最新五年平均 1.307 出版当年[2017版] 1.133 出版当年五年平均 1.205 出版前一年[2016版] 1.313 出版后一年[2018版]

第一作者：

第一作者机构： [a]Department of Hematology/Oncology, First Hospital of Tsinghua University, Beijing, China [*1]Department of Hematology/Oncology First Hospital of Tsinghua University, No. 6, Jiu Xian Qiao 1st Street Chaoyang District, Beijing 100016 (China)

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通讯作者：

通讯机构： [a]Department of Hematology/Oncology, First Hospital of Tsinghua University, Beijing, China [*1]Department of Hematology/Oncology First Hospital of Tsinghua University, No. 6, Jiu Xian Qiao 1st Street Chaoyang District, Beijing 100016 (China)

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