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Associations between Macular Sensitivity and Fixation in Pseudophakic Children after Congenital Cataract Surgery

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机构: [a]Department of Ophthalmology, Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China, [b]Eye Institute of Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China, [c]Key Laboratory of Visual Impairment and Restoration of Shanghai, Fudan University, Shanghai, China, [d]NHC key Laboratory of Myopia, Fudan University, Shanghai, China, [e]Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China, [f]Department of Ophthalmology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
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关键词: axial length congenital cataract fixation stability Macular sensitivity pseudophakic

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Purpose: To investigate the associations between macular sensitivity (MS) and fixation in pseudophakic children after congenital cataract surgery. Materials and Methods: In total 55 pseudophakic eyes and 28 healthy phakic eyes were included in this cross-sectional study. MS and fixation stability in term of 95% bivariate contour ellipse area (BCEA) were assessed with a Macular Integrity Assessment microperimeter. Central foveal thickness (CFT) and subfoveal choroidal thickness (SFCT) was measured with optical coherence tomography. MS inside and outside the 95% BCEA was compared. Influencing factors for the difference in MS between the two regions (ΔMS) were assessed. Results: The overall MS was significantly lower in pseudophakic eyes than in the controls (P < .001). In the pseudophakic group, fixation stability was stable/relatively unstable/unstable in 69.1%/16.4%/14.5% of eyes, and their MS was 27.60 ± 2.56, 25.02 ± 3.82, and 20.50 ± 7.15 dB, respectively. The unstable subgroup had significantly worse MS than the stable subgroup (P < .001). Among pseudophakic eyes, the MS inside the 95% BCEA (fixation preferred region) was significantly greater than that outside this region (P = .048), and it was more correlated with BCVA than that of the entire macula. The ΔMS became greater in those pseudophakic eyes with worse fixation stability (P < .001) and longer axial length (P = .002). Backward stepwise multiple linear regression also revealed 95%BCEA and axial length had significant influences on ΔMS (R2 = 0.289, P < .001). Conclusion: MS was lower in pseudophakic eyes with poor fixation. Macular sensitivity inside and outside the fixation preferred region was different in pseudophakic children after congenital cataract surgery, and this difference increased with longer axial length and poorer fixation. © 2019, © 2019 Taylor & Francis Group, LLC.

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出版当年[2018]版:
大类 | 4 区 医学
小类 | 3 区 眼科学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 眼科学
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出版当年[2017]版:
Q2 OPHTHALMOLOGY
最新[2023]版:
Q3 OPHTHALMOLOGY

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第一作者机构: [a]Department of Ophthalmology, Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China, [b]Eye Institute of Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China, [c]Key Laboratory of Visual Impairment and Restoration of Shanghai, Fudan University, Shanghai, China, [d]NHC key Laboratory of Myopia, Fudan University, Shanghai, China, [e]Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China,
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通讯机构: [a]Department of Ophthalmology, Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China, [b]Eye Institute of Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China, [c]Key Laboratory of Visual Impairment and Restoration of Shanghai, Fudan University, Shanghai, China, [d]NHC key Laboratory of Myopia, Fudan University, Shanghai, China, [e]Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China, [*1]Department of Ophthalmology, Eye and ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China
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