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A clinicopathological comparison between IgA nephropathy and Henoch–Schönlein purpura nephritis in children: use of the Oxford classification

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收录情况： ◇ SCIE

作者：
Xueqian Li[1,2,3,4] * ; Mengmeng Tang[1,2,3,4] ; Xingfeng Yao[4,5] ; Nan Zhang[4,5] ; Jianfeng Fan[1,2,3,4] ; Nan Zhou[1,2,3,4] ; Qiang Sun[1,2,3,4] ; Zhi Chen[1,2,3,4] ; Qun Meng[1,2,3,4] ; Lei Lei[1,2,3,4] ; Hejia Zhang[1,2,3,4] ; Chen Ling[1,2,3,4] ; Lin Hua[6] ; Xiangmei Chen[7] ; Xiaorong Liu[1,2,3,4] ;
机构： [1]Department of Nephrology, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China [2]Beijing Children’s Hemodialysis Center, Beijing 100045, China [3]Beijing Key Laboratory of Pediatric Chronic Kidney Disease and Blood Purification, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China [4]National Center for Children’s Health, Beijing 100045, China [5]Department of Pathology, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China [6]Biostatistics and Bioinformatics, School of Biomedical Engineering, Capital Medical University, Beijing 100069, China [7]Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28th Fuxing Road, Beijing 100853, China
出处：
DOI： 10.1007/s10157-019-01777-8
ISSN：

关键词： Children Clinicopathological Henoch–Schönlein purpura nephritis IgA nephropathy Kidney biopsy The Oxford classification

摘要：
Background: There is controversy over whether IgA nephropathy (IgAN) and Henoch–Schönlein purpura nephritis (HSPN) are the same diseases. This study focuses on the clinicopathological comparison between HSPN and IgAN in children. Methods: Children with IgAN and HSPN who had a diagnostic renal biopsy were enrolled. This study collected the clinical data of patients at biopsy, re-evaluated the pathological lesions of patients according to the Oxford Classification (MEST-C), and made a retrospective comparison between IgAN and HSPN on different stratifications of the course (Tc) and proteinuria. Results: A total of 142 children with IgAN and 57 children with HSPN were enrolled. Various stratification showed the same result, which suggested that IgAN showed more mesangial proliferation (M). HSPN showed more segmental glomerulosclerosis in the Tc > 12 m group than IgAN (S 60.0% vs. 9.10%, P = 0.008). In the non-nephrotic-range and nephrotic-range proteinuria group, there were no significant differences in MEST-C scores between IgAN and HSPN. Conclusion: M is more common in IgAN. HSPN had more S than IgAN over the course of more than 12 months. These results indicate the differences in the pathogenesis in IgAN and HSPN. We propose early biopsy and active treatment of HSPN within 12 months to delay the development of chronic lesions. © 2019, Japanese Society of Nephrology.

基金：
This work was supported by the Capital Health Research and Development of Special Grant (No. 2016-2-2094), the Research on the Application of Capital Clinical Characteristics Program of Beijing Municipal Science and Technology Commission (No. Z161100000516106) and the Project of Beijing Science and Technology Commission (No. D181100000118006).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 4 区 医学
小类 | 4 区 泌尿学与肾脏学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 泌尿学与肾脏学
JCR分区：
出版当年[2017]版：
Q3 UROLOGY & NEPHROLOGY
最新[2023]版：
Q2 UROLOGY & NEPHROLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]Department of Nephrology, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China [2]Beijing Children’s Hemodialysis Center, Beijing 100045, China [3]Beijing Key Laboratory of Pediatric Chronic Kidney Disease and Blood Purification, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China [4]National Center for Children’s Health, Beijing 100045, China
通讯作者：
通讯机构： [1]Department of Nephrology, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China [2]Beijing Children’s Hemodialysis Center, Beijing 100045, China [3]Beijing Key Laboratory of Pediatric Chronic Kidney Disease and Blood Purification, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China [4]National Center for Children’s Health, Beijing 100045, China
推荐引用方式(GB/T 7714)：
Xueqian Li,Mengmeng Tang,Xingfeng Yao,et al.A clinicopathological comparison between IgA nephropathy and Henoch–Schönlein purpura nephritis in children: use of the Oxford classification[J].CLINICAL AND EXPERIMENTAL NEPHROLOGY.2019,23(12):1382-1390.doi:10.1007/s10157-019-01777-8.
APA：
Xueqian Li,Mengmeng Tang,Xingfeng Yao,Nan Zhang,Jianfeng Fan...&Xiaorong Liu.(2019).A clinicopathological comparison between IgA nephropathy and Henoch–Schönlein purpura nephritis in children: use of the Oxford classification.CLINICAL AND EXPERIMENTAL NEPHROLOGY,23,(12)
MLA：
Xueqian Li,et al."A clinicopathological comparison between IgA nephropathy and Henoch–Schönlein purpura nephritis in children: use of the Oxford classification".CLINICAL AND EXPERIMENTAL NEPHROLOGY 23..12(2019):1382-1390

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