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A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome

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收录情况： ◇ SCIE

作者：
Wang, C[] * ; He, H[] ; Sun, B[] ; Liang, L[] ; Li, Y[] ; Wang, H[] ; Wei, L[] ; Li, G[] ; Guo, S[] ; Duan, J[] ; Li, Y[] ; Zhou, Y[] ; Chen, Y[] ; Li, H[] ; Yang, J[] ; Xu, X[] ; Song, L[] ; Chen, J[] ; Bao, Y[] ; Chen, F[] ; Wang, P[] ; Ji, L[] ; Zhang, Y[] ; Ding, Y[] ; Chen, L[] ; Wang, Y[] ; Yang, L[] ; Yang, T[] ; Weng, H[] ; Li, H[] ; Wang, D[] ; Tong, J[] ; Sun, Y[] ; Li, R[] ; Jin, F[] ; Li, C[] ; He, B[] ; Sun, L[] ; Wang, C[] ; Hu, M[] ; Yang, X[] ; Luo, Q[] ; Zhang, J[] ; Tan, H[] ; Liu, B[] ; Hong, R[] ; Yao, X[] ; Lu, F[] ; Wang, H[] ; Wang, L[] ; Tian, H[] ; Wu, Y[] ; Huang, X[] ; Sun, M[] ; Liang, Z[] ; Lin, X[] ; Deng, W[] ; Xu, J[] ; Nan, Y[] ; Shen, N[] ; Li, M[] ;
机构： [a]Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing Engineering Research Center for Diagnosis and Treatment of Pulmonary and Critical Care, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China [b]Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China [c]Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Logistics, College of Chinese Armed Police Forces, Tianjin, China [d]Department of Respiratory and Critical Care Medicine, First Affiliated Hospital, Chongqing Medical University, Chongqing, China [e]Department of Respiratory and Critical Care Medicine, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China [f]Pulmonary Department, Fujian Province Hospital, Fuzhou, Fujian Province, China [g]Department of Respiratory and Critical Care Medicine, Third Affiliated Hospital, Inner Mongolia Medical College, Baotou, Inner Mongolia Autonomous Region, China [h]Pulmonary Department, Xijing Hospital, Fourth Military Medical University, Xi'an, Shanxi Province, China [i]Pulmonary Department, Third People's Hospital of Chengdu, Chengdu, Sichuan Province, China [j]Department of Critical Care Medicine, Chengdu Fifth People's Hospital, Chengdu, Sichuan Province, China [k]Department of Respiratory Medicine, People's Hospital of Beijing, Daxing District, Beijing, China [l]Department of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China [m]Department of Respiratory and Critical Care Medicine, First Affiliated Hospital, Xi'An Jiaotong University, Xi'an, Shanxi Province, China [n]Pulmonary Department, Lung Disease Hospital of Fujian Fuzhou, Fuzhou, Fujian Province, China [o]Pulmonary Department, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China [p]Pulmonary Department, Beijing Tongren Hospital, Beijing, China [q]Department of Respiratory and Critical Care Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shanxi Province, China [r]Pulmonary Department, Peking University, Third Hospital, Beijing, China [s]Pulmonary Department, Xinqiao Hospital, Army Medical University, Chongqing, China [t]Department of Respiratory and Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region, China [u]Department of Respiratory and Critical Care Medicine, General Hospital, Ningxia Medical University, Yinchuan, Ningxia Province, China [v]Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China [w]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, No.2 Yinghua East Road, Chaoyang District, Beijing, 100029, China [x]Department of Respiratory Medicine, Capital Medical University, Beijing, China [y]National Clinical Research Center for Respiratory Diseases, Beijing, China
出处：
DOI： 10.1186/s13054-019-2575-6
ISSN：

关键词： Acute respiratory distress syndrome (ARDS) Noninvasive ventilation (NIV) Pneumonia

摘要：
Rationale: Our pilot study suggested that noninvasive ventilation (NIV) reduced the need for intubation compared with conventional administration of oxygen on patients with "early" stage of mild acute respiratory distress syndrome (ARDS, PaO2/FIO2 between 200 and 300). Objectives: To evaluate whether early NIV can reduce the need for invasive ventilation in patients with pneumonia-induced early mild ARDS. Methods: Prospective, multicenter, randomized controlled trial (RCT) of NIV compared with conventional administration of oxygen through a Venturi mask. Primary outcome included the numbers of patients who met the intubation criteria. Results: Two hundred subjects were randomized to NIV (n = 102) or control (n = 98) groups from 21 centers. Baseline characteristics were similar in the two groups. In the NIV group, PaO2/FIO2 became significantly higher than in the control group at 2 h after randomization and remained stable for the first 72 h. NIV did not decrease the proportion of patients requiring intubation than in the control group (11/102 vs. 9/98, 10.8% vs. 9.2%, p = 0.706). The ICU mortality was similar in the two groups (7/102 vs. 7/98, 4.9% vs. 3.1%, p = 0.721). Multivariate analysis showed minute ventilation greater than 11 L/min at 48 h was the independent risk factor for NIV failure (OR, 1.176 [95% CI, 1.005-1.379], p = 0.043). Conclusions: Treatment with NIV did not reduce the need for intubation among patients with pneumonia-induced early mild ARDS, despite the improved PaO2/FIO2 observed with NIV compared with standard oxygen therapy. High minute ventilation may predict NIV failure. Trial registration: NCT01581229. Registered 19 April 2012 © 2019 The Author(s).

基金：
Research reported in this publication was supported by the National Natural Science Foundation of China 81490534 and National Science and Technology Pillar Program during the 12th Five-year Plan 2012BAI05B02.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 2 区 医学
小类 | 3 区 危重病医学
最新[2023]版：
大类 | 1 区 医学
小类 | 2 区 危重病医学
JCR分区：
出版当年[2017]版：
Q1 CRITICAL CARE MEDICINE
最新[2023]版：
Q1 CRITICAL CARE MEDICINE

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
推荐引用方式(GB/T 7714)：
Wang C,He H,Sun B,et al.A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome[J].CRITICAL CARE.2019,23(1):300.doi:10.1186/s13054-019-2575-6.
APA：
Wang, C,He, H,Sun, B,Liang, L,Li, Y...&Li, M.(2019).A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome.CRITICAL CARE,23,(1)
MLA：
Wang, C,et al."A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome".CRITICAL CARE 23..1(2019):300

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