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Clinical Characteristics and Treatment Outcomes of Pediatric Patients with non-Hodgkin Lymphoma in East Asia.

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机构： [1]Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, Korea, [2]Department of Hematology/Oncology, Shanghai Children’s Medical Center, Shanghai, China, [3]Department of Pediatrics Hematology/Oncology, National Taiwan University Hospital, Taipei, Taiwan, [4]Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan, [5]Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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The presentations and geographic incidence of pediatric non-Hodgkin lymphoma differ from those of adults. This study delineated the characteristics and outcomes of pediatric NHL in East Asia. Medical records of 749 pediatric patients with NHL treated at participating institutions in mainland China, Japan, Korea, and Taiwan from January 2008 to December 2013 were reviewed. Demographic and clinical features, survival outcomes, and putative prognostic factors were analyzed. Five hundred thirty patients (71%) were male. The most common pathologic subtypes were Burkitt lymphoma (BL) (36%). Six hundred seven (81%) patients had advanced diseases at diagnosis. The 5-year overall survival (OS) and event-free survival (EFS) rates were 89% and 84%. The 5-year EFS rates of BL, LL and DLBCL were 88%, 88%, and 89%, and those of ALCL and peripheral T-cell lymphoma (PTCL) were 71% and 56% (P<0.001). CNS involvement, high lactate dehydrogenase level (>250 IU/mL), and advanced disease at diagnosis (≥ stage III) were associated with poor outcomes (P<0.05). ALCL and PTCL relapsed more frequently than other pathologic subtypes (P<0.001). In East Asia, PTCL was more frequent than in Western countries, and BM involvement did not affect treatment outcome. This international study should motivate future collaborative study on NHL in East Asia.

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出版当年[2018]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

第一作者：

第一作者机构： [1]Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, Korea,

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通讯作者：

通讯机构： [1]Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, Korea, [5]Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, Beijing, China [*1]Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea [*2]Department of Lymphoma Hematology/Oncology Center, Beijing Children’s Hospital, Capital Medical University, 56 Nan Lishi Road, Beijing 100045, China

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