Association of polymorphisms of CYP11B2 gene -344C/T and ACE gene I/D with antihypertensive response to angiotensin receptor blockers in Chinese with hypertension.
机构:[1]Department of Cardiology, Beijing Tiantan Hospital, Capital University of Medical Science, Beijing, People’s Republic of China诊疗科室心脏及大血管病中心首都医科大学附属天坛医院
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The aim of this study was to determine whether the polymorphism of aldosterone synthase (CYP11B2) -344C/T and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) were associated with the response of blood pressure (BP) to telmisartan treatment. After a two-week single-blind placebo run-in period, 148 patients with mild-to-moderate primary hypertension received monotherapy of telmisartan with 80 mg/day and then were followed up for eight weeks. Polymorphisms of CYP11B2 -344C/T and ACE I/D gene were determined through polymerase chain reaction-restriction fragment polymorphism analysis. The relationship between these polymorphisms and changes in BP was monitored and evaluated after eight weeks of treatment. With respect tothe polymorphism of CYP11B2 -344C/T, the reduction in diastolic BP was significantly greater in patients carrying the C allele (CC+CT) compared with those carrying the TT genotype. There was no significant differences between ACE I/D polymorphism and BP reduction after treatment. We concluded that the aldosterone synthase -344C/T polymorphism was related to the antihypertensive treatment with telmisartan in hypertensive patients.
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外文
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出版当年[2018]版:
大类|4 区生物
小类|4 区遗传学
最新[2023]版:
大类|4 区生物学
小类|4 区遗传学
第一作者:
第一作者机构:[1]Department of Cardiology, Beijing Tiantan Hospital, Capital University of Medical Science, Beijing, People’s Republic of China
通讯作者:
通讯机构:[1]Department of Cardiology, Beijing Tiantan Hospital, Capital University of Medical Science, Beijing, People’s Republic of China
推荐引用方式(GB/T 7714):
Gong Hongtao,Mu Liying,Zhang Tong,et al.Association of polymorphisms of CYP11B2 gene -344C/T and ACE gene I/D with antihypertensive response to angiotensin receptor blockers in Chinese with hypertension.[J].Journal of genetics.2019,98:
APA:
Gong Hongtao,Mu Liying,Zhang Tong,Xu Xiuying&Du Fenghe.(2019).Association of polymorphisms of CYP11B2 gene -344C/T and ACE gene I/D with antihypertensive response to angiotensin receptor blockers in Chinese with hypertension..Journal of genetics,98,
MLA:
Gong Hongtao,et al."Association of polymorphisms of CYP11B2 gene -344C/T and ACE gene I/D with antihypertensive response to angiotensin receptor blockers in Chinese with hypertension.".Journal of genetics 98.(2019)