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Association of polymorphisms of CYP11B2 gene -344C/T and ACE gene I/D with antihypertensive response to angiotensin receptor blockers in Chinese with hypertension.

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机构: [1]Department of Cardiology, Beijing Tiantan Hospital, Capital University of Medical Science, Beijing, People’s Republic of China
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The aim of this study was to determine whether the polymorphism of aldosterone synthase (CYP11B2) -344C/T and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) were associated with the response of blood pressure (BP) to telmisartan treatment. After a two-week single-blind placebo run-in period, 148 patients with mild-to-moderate primary hypertension received monotherapy of telmisartan with 80 mg/day and then were followed up for eight weeks. Polymorphisms of CYP11B2 -344C/T and ACE I/D gene were determined through polymerase chain reaction-restriction fragment polymorphism analysis. The relationship between these polymorphisms and changes in BP was monitored and evaluated after eight weeks of treatment. With respect tothe polymorphism of CYP11B2 -344C/T, the reduction in diastolic BP was significantly greater in patients carrying the C allele (CC+CT) compared with those carrying the TT genotype. There was no significant differences between ACE I/D polymorphism and BP reduction after treatment. We concluded that the aldosterone synthase -344C/T polymorphism was related to the antihypertensive treatment with telmisartan in hypertensive patients.

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出版当年[2018]版:
大类 | 4 区 生物
小类 | 4 区 遗传学
最新[2023]版:
大类 | 4 区 生物学
小类 | 4 区 遗传学
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第一作者机构: [1]Department of Cardiology, Beijing Tiantan Hospital, Capital University of Medical Science, Beijing, People’s Republic of China
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通讯机构: [1]Department of Cardiology, Beijing Tiantan Hospital, Capital University of Medical Science, Beijing, People’s Republic of China
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