机构：[a]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing,重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[b]China National Clinical Research Center for Neurological Diseases, Beijing,[c]Center of Stroke, Beijing Institute for Brain Disorders, Beijing,[d]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing,[e]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing,[f]Department of Neurology, Yangquan Coalmine Group General Hospital, Yangquan, China
Background and purposeThe association between oxidized low-density lipoprotein (oxLDL) and cognitive impairment is unclear. This study aimed to investigate the potential association between oxLDL and cognitive impairment among patients with acute ischemic stroke. MethodsWe measured the levels of oxLDL and recorded the Mini-Mental State Examination (MMSE) score in patients with acute ischemic stroke who were recruited from the Study of Oxidative Stress in Patients with Acute Ischemic Stroke. Cognitive impairment was defined as an MMSE score of <24. The association between oxLDL and cognitive impairment was assessed by multivariate logistic or linear regression analysis. Other clinical variables of interest were also studied. ResultsA total of 3726 patients [1287 (34.54%) female] were included in this study, with a mean age of 63.6211.96years. After adjusting for potential confounders in our logistic regression model, each SD increase in oxLDL was associated with a 26% increase in the prevalence of cognitive impairment (odds radio, 1.26; 95% confidence interval, 1.13-1.39; P<0.0001). Similarly, higher oxLDL was associated with lower MMSE scores, with a 0.56-point decrease in MMSE score for every SD increase in oxLDL in a linear regression analysis (=-0.56; 95% confidence interval, -0.81 to -0.32; P<0.0001). There were no significant interactions between oxLDL and age, sex or education levels for cognitive impairment (all interactions, P>0.05). ConclusionsElevated levels of oxLDL were associated with a higher prevalence of cognitive impairment in patients with ischemic stroke.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81673247, 816005098]; China Stroke Prevention Project of the National Health and Family Planning Commission
第一作者机构：[a]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing,[b]China National Clinical Research Center for Neurological Diseases, Beijing,[c]Center of Stroke, Beijing Institute for Brain Disorders, Beijing,[d]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing,[e]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing,
共同第一作者：
通讯作者：
通讯机构：[a]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing,[b]China National Clinical Research Center for Neurological Diseases, Beijing,[c]Center of Stroke, Beijing Institute for Brain Disorders, Beijing,[d]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing,[*1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
推荐引用方式(GB/T 7714)：
A. Wang,J. Liu,X. Meng,et al.Association between oxidized low-density lipoprotein and cognitive impairment in patients with ischemic stroke[J].EUROPEAN JOURNAL OF NEUROLOGY.2018,25(1):185-191.doi:10.1111/ene.13497.
APA：
A. Wang,J. Liu,X. Meng,J. Li,H. Wang...&Y. Wang.(2018).Association between oxidized low-density lipoprotein and cognitive impairment in patients with ischemic stroke.EUROPEAN JOURNAL OF NEUROLOGY,25,(1)
MLA：
A. Wang,et al."Association between oxidized low-density lipoprotein and cognitive impairment in patients with ischemic stroke".EUROPEAN JOURNAL OF NEUROLOGY 25..1(2018):185-191
