机构：[1]Shandong Provincial Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou 253023, China,[2]College of Physics and Electronic Information, Dezhou University, Dezhou 253023, China,[3]Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia,[4]Department of Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, China首都医科大学附属天坛医院[5]Institute for Glycomics and School of Information and Communication Technology, Griffith University, Gold Coast, QLD 4222, Australia
Long non-coding RNAs (lncRNAs) play important functional roles in various biological processes. Early databases were utilized to deposit all lncRNA candidates produced by high-throughput experimental and/or computational techniques to facilitate classification, assessment and validation. As more lncRNAs are validated by low-throughput experiments, several databases were established for experimentally validated lncRNAs. However, these databases are small in scale (with a few hundreds of lncRNAs only) and specific in their focuses (plants, diseases or interactions). Thus, it is highly desirable to have a comprehensive dataset for experimentally validated lncRNAs as a central repository for all of their structures, functions and phenotypes. Here, we established EVLncRNAs by curating lncRNAs validated by low-throughput experiments (up to 1May 2016) and integrating specific databases (lncR-NAdb, LncRANDisease, Lnc2Cancer and PLNIncR-Base) with additional functional and disease-specific information not covered previously. The current version of EVLncRNAs contains 1543 lncRNAs from 77 species that is 2.9 times larger than the current largest database for experimentally validated lncRNAs. Seventy-four percent lncRNA entries are partially or completely new, comparing to all existing experimentally validated databases. The established database allows users to browse, search and download as well as to submit experimentally validated lncRNAs. The database is available at http://biophy.dzu.edu.cn/EVLncRNAs.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [61671107, 61271378]; Taishan Scholars Program of Shandong province of China [Tshw201502045]; National Health and Medical Research CouncilNational Health and Medical Research Council of Australia [1059775, 1083450]; National Health and Medical Research Council Early Career FellowshipNational Health and Medical Research Council of Australia [1091816]; Projects of Science and Technology for Colleges and Universities in Shandong Province [J15LE09]; Taishan Young Scholars Program of Shandong province of China [tsqn20161049]; Dezhou University of China [320111]
第一作者机构：[1]Shandong Provincial Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou 253023, China,[2]College of Physics and Electronic Information, Dezhou University, Dezhou 253023, China,
共同第一作者：
通讯作者：
通讯机构：[1]Shandong Provincial Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou 253023, China,[2]College of Physics and Electronic Information, Dezhou University, Dezhou 253023, China,[5]Institute for Glycomics and School of Information and Communication Technology, Griffith University, Gold Coast, QLD 4222, Australia
推荐引用方式(GB/T 7714)：
Zhou Bailing,Zhao Huiying,Yu Jiafeng,et al.EVLncRNAs: a manually curated database for long non-coding RNAs validated by low-throughput experiments[J].NUCLEIC ACIDS RESEARCH.2018,46(D1):D100-D105.doi:10.1093/nar/gkx677.
APA：
Zhou, Bailing,Zhao, Huiying,Yu, Jiafeng,Guo, Chengang,Dou, Xianghua...&Wang, Jihua.(2018).EVLncRNAs: a manually curated database for long non-coding RNAs validated by low-throughput experiments.NUCLEIC ACIDS RESEARCH,46,(D1)
MLA：
Zhou, Bailing,et al."EVLncRNAs: a manually curated database for long non-coding RNAs validated by low-throughput experiments".NUCLEIC ACIDS RESEARCH 46..D1(2018):D100-D105
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