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Interaction of Prussian blue nanoparticles with bovine serum albumin: a multi-spectroscopic approach

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收录情况： ◇ SCIE

作者：

机构： [a]School of Basic Medical Sciences, Capital Medical University, Beijing 100069, P.R. China [b]School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P.R. China [c]Medical Experiment and Test Center, Capital Medical University, Beijing 100069, P.R. China [d]Beijing Neurosurgical Institute, Capital Medical University, Beijing 100069, P.R. China

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关键词： Prussian blue nanoparticals (PBNPs) bovine serum albumin (BSA) interaction fluorescence quenching circular dichroism (CD)

摘要：

Owning to their exceptional properties, Prussian blue nanoparticles (PBNPs) are promising in a variety of biomedical applications. In this scenario, understanding of how PBNPs interact and behave in biological systems is essential. Herein, the interaction of PBNPs with protein was investigated. Specifically, the citric acid stabilized PBNPs with a size of 10 nm were synthesized and characterized. The interactions of these PBNPs with the model protein, bovine serum albumin (BSA), were then probed by spectroscopic methods. It was found that the BSA intrinsic fluorescence was quenched upon addition of PBNPs due to the static interaction, suggesting the binding of PBNPs with BSA. Moreover, the synchronous fluorescence and circular dichroism spectra indicated the conformational change of BSA due to the presence of PBNPs.

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出版当年[2017]版：

大类 | 3 区生物

小类 | 3 区生化与分子生物学 3 区生物物理

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学

JCR分区：

出版当年[2016]版：

Q2 BIOPHYSICS Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 2.7 最新[2023版] 3.2 最新五年平均 3.123 出版当年[2016版] 2.555 出版当年五年平均 2.3 出版前一年[2015版] 3.107 出版后一年[2017版]

第一作者：

第一作者机构： [a]School of Basic Medical Sciences, Capital Medical University, Beijing 100069, P.R. China

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通讯作者：

通讯机构： [b]School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P.R. China [d]Beijing Neurosurgical Institute, Capital Medical University, Beijing 100069, P.R. China

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